CASE REPORT article
Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1615943
Talaromyces marneffei infection associated with pharyngeal and laryngeal injuries in three children with aberrant innate immunity:A case series
Provisionally accepted
- Department of Pediatric Respiratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
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Abstract: Talaromyces marneffei (T. marneffei) is a pathogenic yeast causing high fatality rates among immunocompromised individuals. The organism appears to involve the lungs, liver, gut-associated lymphoid tissues, lymph nodes, spleen, bone marrow, kidneys and the tonsils in the affected individuals. Evidence suggests that lungs and liver are seriously injured in T. marneffei infections. Injuries to the pharyngeal and laryngeal compartments are seldom reported. Case presentation: Three pediatric patients with T. marneffei infection were admitted to the Guangzhou Women and Children's Center from August 2015 to March 2023. All three children showed evidence of pharyngeal and laryngeal injuries. Conclusions: Damage to the pharyngeal and laryngeal compartments appears to be an important clinical manifestation among HIV-negative pediatric individuals with T. marneffei infection.
Keywords: Talaromyces marneffei, Children, Pharyngeal, laryngeal, Infection
Received: 22 Apr 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Zhang, Lu, Xu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huifeng Fan, sonny-000@163.com
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