Structure Based Drug Discovery | List of Frontiers open access articles

Original Research

Published on 14 Oct 2025

Investigation on the relationship between renal NONO expression, fibrosis and prognosis in diabetic nephropathy

in Renal Endocrinology

Shuang Yang
Huiyuan Liao
Hanlu Ding
Xingli Xu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1652391

471 views

Case Report

Published on 14 Oct 2025

Pathological complete response to conversion therapy for lung adenocarcinoma with brain metastasis: a case report

in Thoracic Oncology

Xingqiang Ran
Tao Luo
Jie Xiong
Maoyong Fu

Frontiers in Oncology

doi 10.3389/fonc.2025.1625918

297 views

Original Research

Published on 14 Oct 2025

MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway

in Diabetes: Molecular Mechanisms

Juan Zhang
Xiyin Zheng
Hong Zhang
Juan Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669791

405 views

Original Research

Published on 14 Oct 2025

Comprehensive dietary antioxidant index and chronic kidney disease: mediating role of frailty and its impact on mortality outcomes in adults

in Clinical Nutrition

Wenqing Li
Shuang Chen
Jiangmin Wan
Liyuan Chen
Lingzhi Xing
Zhenglan Gao
Ling Chen

Frontiers in Nutrition

doi 10.3389/fnut.2025.1679774

273 views

Original Research

Published on 14 Oct 2025

Histopathology of Aculeastrum americanum on Rubus idaeus and insights into the chloroplast-pathogen interaction

in Plant Pathogen Interactions

Lucas Henrique Santos Barbosa
Ulla Neumann
Ton Timmers
Tonni Grube Andersen
Beatriz Appezzato-da-Glória

Frontiers in Plant Science

doi 10.3389/fpls.2025.1630100

402 views

Review

Published on 14 Oct 2025

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

in Computational Genomics

P. Balakrishnan
A. Anny Leema
V. Dhivya Shree
C. Mohammad Saad
A. Mohan Babu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634882

531 views

Original Research

Published on 14 Oct 2025

Integrative multi-omics reveals energy metabolism–related prognostic signatures and immunogenetic landscapes in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Lei Xie
Yajie Zhou
Zijian Hu
Wenxiong Zhang
Xiaoqiang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679464

193 views

Original Research

Published on 14 Oct 2025

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

in Experimental Pharmacology and Drug Discovery

Zhuo Song
Xiuci Yan
Xiaohao Xu
Tingting Lou
Yu Wang
Limei Ren
Fangbing Liu
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657436

703 views

Mini Review

Published on 14 Oct 2025

Touch restriction during small-sided games in soccer—effects on physiological, physical and technical and tactical performance

in Sports Coaching: Performance and Development

Michael C. Rumpf
Johannes Jäger
Stefan Altmann
Matthias Lochmann

Frontiers in Sports and Active Living

doi 10.3389/fspor.2025.1705921

156 views

Original Research

Published on 14 Oct 2025

Understanding the relationship between social media use for information acquisition and life satisfaction from a knowledge, beliefs, and practices perspective

in Health Psychology

Mengru Sun

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1678675

201 views

Original Research

Published on 14 Oct 2025

Existential concerns, community integration and psychological depression among female stroke survivors in Nigeria

in Preventative Health and Stroke Complications

Olubukola A. Olaleye
Ayomide T. Olajide

Frontiers in Stroke

doi 10.3389/fstro.2025.1635705

1,098 views

Review

Published on 14 Oct 2025

Recent progress in the development of etomidate analogues

in Experimental Pharmacology and Drug Discovery

Yanting Chen
Lan Wu
Bingchen Lang
Wensheng Zhang
Shouming Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614865

160 views

Review

Published on 14 Oct 2025

Syzygium aromaticum (clove buds) as a natural antibacterial agent: a promising alternative to combat multidrug-resistant bacteria

in Antimicrobials, Resistance and Chemotherapy

Hira Tariq
Abdulrahman Mohammed Alhudhaibi
Emad M. Abdallah

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1674590

290 views

Review

Published on 14 Oct 2025

Metabolic syndrome in colorectal cancer liver metastasis: metabolic reprogramming and microenvironment crosstalk

in Cancer Immunity and Immunotherapy

Zheng Ma
Song Wang
Shanglong Liu
Wenchang Yang
Jilin Hu
Lianghong Lv
Qian Yu
Yun Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653442

220 views

Systematic Review

Published on 14 Oct 2025

Trends and developments in health systems modeling: a bibliometric analysis

in Health Informatics

Kudakwashe Maguraushe
Patrick Ndayizigamiye
Tebogo Bokaba

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1595310

277 views

Original Research

Published on 14 Oct 2025

The relationship between Chinese medical students' learning motivation and learning engagement: a network analysis

in Educational Psychology

Dengqin Wang
Peibo Song
Qianqian Zhang
Huili Zhao
Bo Zhuang

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1611900

446 views

Articles

Investigation on the relationship between renal NONO expression, fibrosis and prognosis in diabetic nephropathy

Pathological complete response to conversion therapy for lung adenocarcinoma with brain metastasis: a case report

MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway

Comprehensive dietary antioxidant index and chronic kidney disease: mediating role of frailty and its impact on mortality outcomes in adults

Histopathology of Aculeastrum americanum on Rubus idaeus and insights into the chloroplast-pathogen interaction

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

Integrative multi-omics reveals energy metabolism–related prognostic signatures and immunogenetic landscapes in lung adenocarcinoma

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

Touch restriction during small-sided games in soccer—effects on physiological, physical and technical and tactical performance

Understanding the relationship between social media use for information acquisition and life satisfaction from a knowledge, beliefs, and practices perspective

Existential concerns, community integration and psychological depression among female stroke survivors in Nigeria

Recent progress in the development of etomidate analogues

Syzygium aromaticum (clove buds) as a natural antibacterial agent: a promising alternative to combat multidrug-resistant bacteria

Metabolic syndrome in colorectal cancer liver metastasis: metabolic reprogramming and microenvironment crosstalk

Trends and developments in health systems modeling: a bibliometric analysis

The relationship between Chinese medical students' learning motivation and learning engagement: a network analysis