Aging Neuroscience

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Aging Neuroscience

Aging neuroscience explores how the brain changes over time and what drives cognitive decline, resilience, and neurodegeneration. Our Research Topics examine the biological, psychological, and environmental factors shaping brain aging, from molecular mechanisms to clinical interventions. By advancing understanding across disciplines, we aim to support healthier aging and improve brain health worldwide.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of synaptic neuroscience. These Research Topics are published in the peer-reviewed journal Frontiers in Aging Neuroscience, as open access articles.

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

Woman helping senior woman dress in her bedroom

To Know or Not to Know: Causes and Evolution of Lack of Awareness of Cognitive Decline in Neurodegenerative Diseases Vol III

The aim of this Research Topic is to invite contributions that investigate the mechanism of anosognosia as well as the evolution of altered awareness across the different stages of neurodegenerative diseases.

Neurons and nervous system. 3d render of nerve cells

Cognitive Decline in Older Adults with Epilepsy: Mechanisms, Risk Stratification, and Therapeutic Implications.

The primary challenge addressed by this Research Topic is the insufficient understanding and management of cognitive decline in older adults with epilepsy.

Amyloid plaques in Alzheimer's disease, 3d illustration

Evolution of Cognitive Assessment Tools in Dementia Research

The primary goal of this Research Topic is to critically examine the evolution of cognitive assessment instruments, identifying both advancements and persistent gaps.

Intertwining Paths: Sensorimotor and Cognitive Dynamics in Neurocognitive Aging

This Research Topic seeks to deepen our understanding of the bidirectional relationship between sensorimotor and cognitive systems in aging. It aims to uncover how changes in sensorimotor function contribute to cognitive decline and conversely, how...

Elderly 80s man patient and middle-aged nurse medical worker holding clipboard writing personal information having pleasant warm conversation talk with clinic client nursing caregiving service concept

Understanding IGF-I's impact on neurocognitive aging: insights and therapeutic directions

The goal of this Research Topic is to advance our understanding of how IGF-I signaling influences neurocognitive trajectories in the aging brain and to identify innovative strategies for harnessing IGF-I and related pathways in the prevention or...

Computational tools in Alzheimer’s Disease: advancing precision medicine and protecting neurorights

The goal of this Research Topic is to bring together the latest empirical and computational studies on brain stimulation in the context of Alzheimer’s disease to foster a dialogue between neurotechnology and clinical trials.

Beta-amyloid (Abeta) peptide, 3D rendering. Major component of plaques found in Alzheimer's disease.Stick representation combined with semi-transparent molecular surface.

Navigating Alzheimer's Pathogenesis and Treatment: Debates on Amyloid-Beta Therapies and Emerging Alternatives

This Research Topic aims to provide a platform to investigate the current state and future directions of Alzheimer’s disease therapeutics.

Sweet shot of happy young woman of mixed race appearance sitting in chair, breastfeeding her infant son, enjoying deep connection with child. Love, family, relationships and togetherness concept

Tracing Maternal Nutrition's Legacy on Neuroinflammation from Neurodevelopment to Adult life

This research topic aims at updating understanding of how maternal and progeny nutritional and nonnutritional factors shape short and long term neuroinflammation, focusing on how dietary nutrients modulate neuronal excitability, brain metabolism, and...

Connections between the substancia nigra and the thalamus in a Parkinson's brain

Current Status of Diagnosis and Differential Diagnosis of Parkinson's disease and Parkinson's syndromes

This research topic aims at advancing personalized diagnosis of Parkinson’s and atypical parkinsonism by reviewing current and emerging tools, clarifying motor and non-motor subtypes, identifying limitations and gaps, and...

Vagus nerve with painful stomach and digestive system, 3D medically illustration on black background

Decoding the Gut-Brain Axis: Implications for Neurodegenerative Disease Therapies

This Research Topic aims to advance our knowledge of the gut-brain axis and its implications for neurodegenerative disease therapies.

Medical scientists presenting in the brain research laboratory by monitor showing MRI, CT scans brain images. Female scientist working and consider magnetic resonance image (MRI) of the brain.

Women in Aging Neuroscience: Neurodegenerative Disorders

This research topic aims at highlighting and promoting women-led advances in aging neuroscience on neurodegenerative disorders, showcasing innovations in mechanisms, diagnosis, treatment, and management, addressing barriers in research and care, and...

Machine Learning Revolutionizing Aging-Related Movement Disorder Diagnostics

This Research Topic aims to explore the innovative application of machine learning techniques in the diagnosis and management of aging-related movement disorders.

Microglia are immune cells in the brain, 3d illustration

Microglia and Neuroinflammation: A Journey Through Brain Aging and Neurodegeneration

This Research Topic will explore the role of microglia in aging and neurodegeneration, gathering studies on the molecular and cellular mechanisms underlying microglial activation and dysfunction during aging.

an array of positron emission tomography or PET images showing many phases of brain perfusion function and activity

Imaging Biomarkers in Neurodegenerative Diseases: Advances and Challenges

This Research Topic seeks to gather cutting-edge research on novel imaging biomarkers that improve the detection and understanding of neurodegenerative processes.

Close up hands of asian senior elderly woman with parkinson's disease symptom, hand numbness, finger lock, hand pain. Mental health and elderly care concept

Biomarkers for early detection and progression of Parkinson’s Disease: Integrating genomic, proteomic, imaging, and clinical advances

This Research Topic focuses on advancing our understanding of biomarkers across multiple disciplines to facilitate earlier diagnosis and track disease progression.

Astrocyte-neuron communication through chemical signals. Protoplasmic astrocytes (violet) play an active role in memory and learning through communication with neurons. 3d rendering

Astrocytes and Immunity: Unveiling Their Role in Pain and Neurodegenerative Disease Progression

This research topic aims at advancing understanding of astrocyte immune interactions in chronic pain and neurodegeneration including mast cell astrocyte crosstalk BBB integrity calcium signaling aging effects and therapeutic targeting to improve outcomes.

Woman helping senior woman dress in her bedroom

To Know or Not to Know: Causes and Evolution of Lack of Awareness of Cognitive Decline in Neurodegenerative Diseases Vol III

The aim of this Research Topic is to invite contributions that investigate the mechanism of anosognosia as well as the evolution of altered awareness across the different stages of neurodegenerative diseases.

Neurons and nervous system. 3d render of nerve cells

Cognitive Decline in Older Adults with Epilepsy: Mechanisms, Risk Stratification, and Therapeutic Implications.

The primary challenge addressed by this Research Topic is the insufficient understanding and management of cognitive decline in older adults with epilepsy.

Amyloid plaques in Alzheimer's disease, 3d illustration

Evolution of Cognitive Assessment Tools in Dementia Research

The primary goal of this Research Topic is to critically examine the evolution of cognitive assessment instruments, identifying both advancements and persistent gaps.

Intertwining Paths: Sensorimotor and Cognitive Dynamics in Neurocognitive Aging

This Research Topic seeks to deepen our understanding of the bidirectional relationship between sensorimotor and cognitive systems in aging. It aims to uncover how changes in sensorimotor function contribute to cognitive decline and conversely, how...

Elderly 80s man patient and middle-aged nurse medical worker holding clipboard writing personal information having pleasant warm conversation talk with clinic client nursing caregiving service concept

Understanding IGF-I's impact on neurocognitive aging: insights and therapeutic directions

The goal of this Research Topic is to advance our understanding of how IGF-I signaling influences neurocognitive trajectories in the aging brain and to identify innovative strategies for harnessing IGF-I and related pathways in the prevention or...

Computational tools in Alzheimer’s Disease: advancing precision medicine and protecting neurorights

The goal of this Research Topic is to bring together the latest empirical and computational studies on brain stimulation in the context of Alzheimer’s disease to foster a dialogue between neurotechnology and clinical trials.

Beta-amyloid (Abeta) peptide, 3D rendering. Major component of plaques found in Alzheimer's disease.Stick representation combined with semi-transparent molecular surface.

Navigating Alzheimer's Pathogenesis and Treatment: Debates on Amyloid-Beta Therapies and Emerging Alternatives

This Research Topic aims to provide a platform to investigate the current state and future directions of Alzheimer’s disease therapeutics.

Sweet shot of happy young woman of mixed race appearance sitting in chair, breastfeeding her infant son, enjoying deep connection with child. Love, family, relationships and togetherness concept

Tracing Maternal Nutrition's Legacy on Neuroinflammation from Neurodevelopment to Adult life

This research topic aims at updating understanding of how maternal and progeny nutritional and nonnutritional factors shape short and long term neuroinflammation, focusing on how dietary nutrients modulate neuronal excitability, brain metabolism, and...

Connections between the substancia nigra and the thalamus in a Parkinson's brain

Current Status of Diagnosis and Differential Diagnosis of Parkinson's disease and Parkinson's syndromes

This research topic aims at advancing personalized diagnosis of Parkinson’s and atypical parkinsonism by reviewing current and emerging tools, clarifying motor and non-motor subtypes, identifying limitations and gaps, and...

Vagus nerve with painful stomach and digestive system, 3D medically illustration on black background

Decoding the Gut-Brain Axis: Implications for Neurodegenerative Disease Therapies

This Research Topic aims to advance our knowledge of the gut-brain axis and its implications for neurodegenerative disease therapies.

Medical scientists presenting in the brain research laboratory by monitor showing MRI, CT scans brain images. Female scientist working and consider magnetic resonance image (MRI) of the brain.

Women in Aging Neuroscience: Neurodegenerative Disorders

This research topic aims at highlighting and promoting women-led advances in aging neuroscience on neurodegenerative disorders, showcasing innovations in mechanisms, diagnosis, treatment, and management, addressing barriers in research and care, and...

Machine Learning Revolutionizing Aging-Related Movement Disorder Diagnostics

This Research Topic aims to explore the innovative application of machine learning techniques in the diagnosis and management of aging-related movement disorders.

Microglia are immune cells in the brain, 3d illustration

Microglia and Neuroinflammation: A Journey Through Brain Aging and Neurodegeneration

This Research Topic will explore the role of microglia in aging and neurodegeneration, gathering studies on the molecular and cellular mechanisms underlying microglial activation and dysfunction during aging.

an array of positron emission tomography or PET images showing many phases of brain perfusion function and activity

Imaging Biomarkers in Neurodegenerative Diseases: Advances and Challenges

This Research Topic seeks to gather cutting-edge research on novel imaging biomarkers that improve the detection and understanding of neurodegenerative processes.

Close up hands of asian senior elderly woman with parkinson's disease symptom, hand numbness, finger lock, hand pain. Mental health and elderly care concept

Biomarkers for early detection and progression of Parkinson’s Disease: Integrating genomic, proteomic, imaging, and clinical advances

This Research Topic focuses on advancing our understanding of biomarkers across multiple disciplines to facilitate earlier diagnosis and track disease progression.

Astrocyte-neuron communication through chemical signals. Protoplasmic astrocytes (violet) play an active role in memory and learning through communication with neurons. 3d rendering

Astrocytes and Immunity: Unveiling Their Role in Pain and Neurodegenerative Disease Progression

This research topic aims at advancing understanding of astrocyte immune interactions in chronic pain and neurodegeneration including mast cell astrocyte crosstalk BBB integrity calcium signaling aging effects and therapeutic targeting to improve outcomes.