Imaging Biomarkers in Neurodegenerative Diseases: Advances and Challenges

Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and other age-related disorders are emerging as critical public health challenges. Despite significant progress in understanding their underlying pathologies, early and accurate diagnosis remains complex. Current imaging techniques, particularly magnetic resonance imaging (MRI) and positron emission tomography (PET), have revolutionized our approach to diagnosing and monitoring these conditions. However, conventional imaging biomarkers often lack sensitivity and specificity at the early stages of disease.

This Research Topic seeks to gather cutting-edge research on novel imaging biomarkers that improve the detection and understanding of neurodegenerative processes. We welcome submissions that explore innovative MRI technologies and PET imaging methods, including multiparametric MRI, molecular PET imaging probes, and hybrid techniques that integrate structural and functional information. Emphasis is placed on studies that demonstrate potential clinical applications, validate biomarkers in larger cohorts, and address the challenges of translating experimental findings into routine clinical practice.

Together, these contributions will provide valuable insights into advancing early diagnosis, monitoring disease progression, and evaluating novel therapeutic interventions. We invite the scientific community to share original research, reviews, and methodological innovations to further the development of next-generation imaging biomarkers in neurodegenerative diseases.

Topic Editor Dr Luca Caldi Gomes is employed by NanoTemper Technologies. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Keywords: neuroimaging, biomarkers, neurodegeneration

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.