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Oncology

The following Research Topics are led by experts in their field and contribute to the scientific understanding of oncology. These Research topics are published in the peer-reviewed journal Frontiers in Oncology, as open access articles.

Oncology is a specialized field of medicine that focuses on the prevention, diagnosis, and treatment of various types of cancer. Our Research Topics explore key advancements in oncology which have led to significant breakthroughs in cancer care, such as targeted therapies, immunotherapy, and precision medicine.

Senior woman lying in hospital room after chemotherapy.; Shutterstock ID 2253072095; purchase_order: -; job: -; client: -; other: -

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

Woman Receiving Radiation Therapy Medical Treatment for Cancer

Neoadjuvant Therapy in HNSCC

The goal of this Research Topic is to generate a discussion of how neoadjuvant therapy affects HNSCC patients and the potential benefits, challenges and ongoing research which could provide valuable insights into improving treatment outcomes.

Macrophage devouring a cancer cell, immune cells capable of physically ingesting damaged or diseased cells, cancer immunotherapy. 3D Render

Formation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic Potential

The primary goal of this Research Topic is to deepen our understanding of the formation and function of immunological niches within the tumor microenvironment and their role in cancer progression and immune evasion.

Stomach (gastric) cancer histology: Microscopic image of a poorly differentiated gastric adenocarcinoma, signet ring cell type (photographed and uploaded by US board-certified surgical pathologist).

Primary and Secondary Chemotherapy Resistance in Gastrointestinal Tumors: Key Mechanisms and Ways to Overcome Resistance

This Research Topic aims to comprehensively explore the underlying mechanisms of chemotherapy resistance in GI tumors and to discuss innovative strategies to counteract these resistance pathways.

a sagittal cut of magnetic resonance image or MRI showing brain and spinal cord on black background

Multidisciplinary Management of Skull-Base Tumours

This research topic is designed to provide a platform for researchers, clinicians, and experts from various disciplines to share their insights and contribute to the evolving landscape of skull-base cancer management.

Dividing breast cancer cell.It is in the telophase stage of cell division.Cancerous breast cells form tumours, which possess the ability to invade surrounding tissues.

Challenges and Strategies in the Management of ER/PgR Low-Expression Breast Cancer: Exploring Fundamentals, Clinical Insights, and Treatment Approaches

This research topic aims to delve into the complexities of hormone receptor-low expression breast cancer, an emerging and significant subtype.

Lasers are used to position a patient model wearing a short face mask in a computed tomography (CT) scanner to obtain images of a tumor before radiation therapy. 2010

Technology Developments in Proton Therapy

Background: Proton therapy is a radiation cancer therapy modality that aims to irradiate tumors with submillimeter precision.

Tumor microenvironment, normal cells, molecules, and blood vessels that surround and feed a tumor cell. Microenvironment can affect how a tumor grows and spreads. 3d illustration

The Immunosuppressive Microenvironment in Pediatric Cancers: Applications and Considerations in Immunotherapy

The overarching goal of this research topic is to enhance the efficacy of immunotherapy in pediatric cancers by deciphering and modulating the immunosuppressive microenvironment.

Young Woman Receiving Radiation Therapy Treatments for Cancer

Uncertainty Quantification in AI Methods for Radiation Oncology Application

This Research Topic aims to promote research in AI uncertainty quantification and application as a high impact research field, with a mixture of both academic and clinical interest.

a lateral view X-ray of mammogram showing breast mass.

Circulating Tumor DNA Assays and Breast Cancer Management Evolution: Present and Future

In this very rapidly evolving field, this Research Topic aims to review and explore the field of liquid biopsies in breast cancer, with a focus on ctDNA.

Pancreatic cancer cells closeup 3d render illustration

The Role and Potential Applications of the Microbiota in Pancreatic Ductal Adenocarcinoma

Background: Given the current state of scientific literature, there is a relative scarcity of information regarding the molecular pathways involved in the cross-talk between PC and microrganisms.

T-cell receptor, CD-4, CD-28, PD-1 and CTLA-4 and a calcium channel on a T-cell
TCR (blue), CD-4 (light blue), CD-28 (dark blue), PD-1 (magenta), CTLA-4 (violet), Ca-channel (violet), 3d rendering

Immune Checkpoints Regulatory Mechanisms and Immunotherapy Strategies in Gastrointestinal Tumors

This Research Topic aims to collect original research on the regulatory mechanisms and immunotherapy strategies of immune checkpoints for gastrointestinal tumors and discuss the regulation of immune checkpoint inhibitors and molecular targeted therapy...

Medical Hospital: Happy Neurologist and Neurosurgeon Talk, Use Computer, Analyse Patient MRI Scan, Diagnose Brain. Brain Health Research Clinic: Two Smiling Physicians Look at CT Scan find Treatment

Cancer Epidemiology and Etiology Evaluation in Latin American Population

We aim to collect studies on the molecular characterization of cancer in Latin America, focusing on data from cutting-edge technologies like next-Generation sequencing, single-Cell RNA sequencing, and liquid biopsy, among others.

Tumor ulceration and veins cancer cells mutating, tumor growth on mucosa 3d rendering

Clonal Heterogeneity and Tumor Evolution: Implications for Cancer Therapy

This research topic aims to highlight the latest advances in tumor evolution and heterogeneity.

Magnetic resonance imaging (MRI)

Methods and Applications of Tumour Metabolic Imaging in the Preclinical and Clinical Setting

The aim of this research topic is to collect cancer metabolism studies performed in preclinical and clinical settings using non-invasive medical imaging methods.

Mother visiting teen son with cancer in hospital ward. Side view of bald kid resting in hospital bed and hugging mother visitor. Healthcare and medicine concept

Refractory and Relapsed Hemophagocytic Lymphohistiocytosis in Pediatric Population: Targeted Therapy

Background: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disease, that occurs in children, characterized by hyperinflammation consecutive to immune dysregulation.

T Cells attacking Cancer Cells 3D illustration

The Emerging role of Blood-based Biomarkers for the Immunologic Characterization and Therapy of Cancer

This Research Topic aims to give a broad overview of the emerging technologies, prospects, but also limitations for blood-based biomarkers to assess the immunologic status and guide therapy of cancer patients.

Woman Receiving Radiation Therapy Medical Treatment for Cancer

Neoadjuvant Therapy in HNSCC

The goal of this Research Topic is to generate a discussion of how neoadjuvant therapy affects HNSCC patients and the potential benefits, challenges and ongoing research which could provide valuable insights into improving treatment outcomes.

Macrophage devouring a cancer cell, immune cells capable of physically ingesting damaged or diseased cells, cancer immunotherapy. 3D Render

Formation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic Potential

The primary goal of this Research Topic is to deepen our understanding of the formation and function of immunological niches within the tumor microenvironment and their role in cancer progression and immune evasion.

Stomach (gastric) cancer histology: Microscopic image of a poorly differentiated gastric adenocarcinoma, signet ring cell type (photographed and uploaded by US board-certified surgical pathologist).

Primary and Secondary Chemotherapy Resistance in Gastrointestinal Tumors: Key Mechanisms and Ways to Overcome Resistance

This Research Topic aims to comprehensively explore the underlying mechanisms of chemotherapy resistance in GI tumors and to discuss innovative strategies to counteract these resistance pathways.

a sagittal cut of magnetic resonance image or MRI showing brain and spinal cord on black background

Multidisciplinary Management of Skull-Base Tumours

This research topic is designed to provide a platform for researchers, clinicians, and experts from various disciplines to share their insights and contribute to the evolving landscape of skull-base cancer management.

Dividing breast cancer cell.It is in the telophase stage of cell division.Cancerous breast cells form tumours, which possess the ability to invade surrounding tissues.

Challenges and Strategies in the Management of ER/PgR Low-Expression Breast Cancer: Exploring Fundamentals, Clinical Insights, and Treatment Approaches

This research topic aims to delve into the complexities of hormone receptor-low expression breast cancer, an emerging and significant subtype.

Lasers are used to position a patient model wearing a short face mask in a computed tomography (CT) scanner to obtain images of a tumor before radiation therapy. 2010

Technology Developments in Proton Therapy

Background: Proton therapy is a radiation cancer therapy modality that aims to irradiate tumors with submillimeter precision.

Tumor microenvironment, normal cells, molecules, and blood vessels that surround and feed a tumor cell. Microenvironment can affect how a tumor grows and spreads. 3d illustration

The Immunosuppressive Microenvironment in Pediatric Cancers: Applications and Considerations in Immunotherapy

The overarching goal of this research topic is to enhance the efficacy of immunotherapy in pediatric cancers by deciphering and modulating the immunosuppressive microenvironment.

Young Woman Receiving Radiation Therapy Treatments for Cancer

Uncertainty Quantification in AI Methods for Radiation Oncology Application

This Research Topic aims to promote research in AI uncertainty quantification and application as a high impact research field, with a mixture of both academic and clinical interest.

a lateral view X-ray of mammogram showing breast mass.

Circulating Tumor DNA Assays and Breast Cancer Management Evolution: Present and Future

In this very rapidly evolving field, this Research Topic aims to review and explore the field of liquid biopsies in breast cancer, with a focus on ctDNA.

Pancreatic cancer cells closeup 3d render illustration

The Role and Potential Applications of the Microbiota in Pancreatic Ductal Adenocarcinoma

Background: Given the current state of scientific literature, there is a relative scarcity of information regarding the molecular pathways involved in the cross-talk between PC and microrganisms.

T-cell receptor, CD-4, CD-28, PD-1 and CTLA-4 and a calcium channel on a T-cell
TCR (blue), CD-4 (light blue), CD-28 (dark blue), PD-1 (magenta), CTLA-4 (violet), Ca-channel (violet), 3d rendering

Immune Checkpoints Regulatory Mechanisms and Immunotherapy Strategies in Gastrointestinal Tumors

This Research Topic aims to collect original research on the regulatory mechanisms and immunotherapy strategies of immune checkpoints for gastrointestinal tumors and discuss the regulation of immune checkpoint inhibitors and molecular targeted therapy...

Medical Hospital: Happy Neurologist and Neurosurgeon Talk, Use Computer, Analyse Patient MRI Scan, Diagnose Brain. Brain Health Research Clinic: Two Smiling Physicians Look at CT Scan find Treatment

Cancer Epidemiology and Etiology Evaluation in Latin American Population

We aim to collect studies on the molecular characterization of cancer in Latin America, focusing on data from cutting-edge technologies like next-Generation sequencing, single-Cell RNA sequencing, and liquid biopsy, among others.

Tumor ulceration and veins cancer cells mutating, tumor growth on mucosa 3d rendering

Clonal Heterogeneity and Tumor Evolution: Implications for Cancer Therapy

This research topic aims to highlight the latest advances in tumor evolution and heterogeneity.

Magnetic resonance imaging (MRI)

Methods and Applications of Tumour Metabolic Imaging in the Preclinical and Clinical Setting

The aim of this research topic is to collect cancer metabolism studies performed in preclinical and clinical settings using non-invasive medical imaging methods.

Mother visiting teen son with cancer in hospital ward. Side view of bald kid resting in hospital bed and hugging mother visitor. Healthcare and medicine concept

Refractory and Relapsed Hemophagocytic Lymphohistiocytosis in Pediatric Population: Targeted Therapy

Background: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disease, that occurs in children, characterized by hyperinflammation consecutive to immune dysregulation.

T Cells attacking Cancer Cells 3D illustration

The Emerging role of Blood-based Biomarkers for the Immunologic Characterization and Therapy of Cancer

This Research Topic aims to give a broad overview of the emerging technologies, prospects, but also limitations for blood-based biomarkers to assess the immunologic status and guide therapy of cancer patients.