Oncology

Skip to main content

Oncology

Frontiers in Oncology is a multidisciplinary journal publishing research that advances the understanding, diagnosis, and treatment of cancer. It covers the full spectrum of oncology, including basic, clinical, and translational research across all tumor types and therapeutic approaches.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of oncology. These Research topics are published in the peer-reviewed journal Frontiers in Oncology, as open access articles.

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

Breast Cancer Awareness: Immunohistochemistry for HER2 shows positive cell membrane staining in this infiltrating ductal carcinoma. This patient will benefit for herceptin (trastuzumab) therapy.

Exploring the Breast Tumor Microenvironment: Association to Metastasis, Novel Risk Factors and Novel Treatments and Immunotherapies: Volume II.

This Research Topic compiles the latest information on the biological factors associated with the tumour microenvironment and anti-cancer mechanisms.

Next-Generation Radiotherapy for Prostate Cancer: Precision, Personalization, and Technological Advances

This Research Topic delves into the innovative strategies and technologies that are setting the stage for a new era in prostate cancer radiotherapy.

Human colorectal cancer cells treated with a topoisomerase inhibitor and an inhibitor of the protein kinase ATR (ataxia telangiectasia and Rad3 related), a drug combination under study as a cancer therapy. Cell nuclei are stained blue; the chromosomal protein histone gamma-H2AX marks DNA damage in red and foci of DNA replication in green. Created by Yves Pommier, Rozenn Josse, 2014

National Colorectal Cancer Awareness Month 2025: Current Progress and Future Prospects on Colorectal Cancer Prevention, Diagnosis and Treatment

This Research Topic highlights innovations in colorectal cancer research, including early detection, precision medicine, immunotherapy, and microbiome-based strategies, aiming to advance diagnosis in support of Colorectal Cancer Awareness Month.

Hospital Radiology Room: Multiethnic Woman Standing in Medical Gown in the X-Ray Machine. Adult Female Undergoes Healthcare Exam and is Scanning Chest, Heart, Lungs in Modern Clinic Office.

Advancing Diagnostic Excellence in Early Lung Cancer Detection

This Research Topic highlights diagnostic excellence, which encapsulates achieving an accurate, precise, and timely diagnosis while adhering to the highest standards of patient safety, care, and equity.

T Cells attacking Cancer Cells 3D illustration

National Cancer Research Month 2025: Advances in Detection, Treatment and Therapies in Oncology

This Research Topic provides a platform to spotlight the latest advancements and collaborative efforts that fuel ongoing innovations to improve cancer research and, ultimately, improve patient outcomes and prognosis.

Woman in white robe smiling and looking out the window

Comprehensive Management and Risk Assessment of Breast Cancer-Related Lymphedema: A Multidisciplinary Approach

This Research Topic explores BCRL by investigating risk factors, refining diagnostic approaches, and assessing the efficacy of emerging treatments.

Ribonucleic acid or RNA molecule 3D Rendering. RNA is most often single-stranded 3d rendered.

Transforming Cancer Treatment: The Clinical Potentials of Non-Coding RNAs

This Research Topic explores how ncRNAs can be leveraged to inform clinical decision-making, from diagnostics to therapeutics, with a focus on real-world applications in oncology.

Double helix DNA molecule with modified genes , Correcting mutation by genetic engineering , 3d illustration

Gynecological Cancer Prevention in Women With Inherited Genetic Risk

This Research Topic explores pathogenic mutations linked to gynecological cancer risk, focusing on carrier identification, preventive strategies, and management of high-risk individuals, as well as genetic influences on anticancer drug response.

human female ovary 3D

Evidence-Based Implementation of Innovations in Gynecological Oncology

This Research Topic highlights key advancements, challenges, and the role of collaborative expertise in transforming gynaecologic oncology care.

This Centers for Disease Control and Prevention (CDC) scientist was loading patient samples into an automated instrument, used to test the samples for SARS-CoV-2 antibodies - a sign of past infection by the virus that causes COVID-19 - using the CDC serologic test.

Real-World Clinical and Translational Research in Gastrointestinal Cancers

This Research Topic highlights real-world clinical and translational studies in GI cancers, with a focus on rare tumors and innovative methods like AI, organoids, and metabolomics to inform treatment decisions beyond traditional RCT evidence.

Cancer cells can migrate to other body tissues or organs building metastasis. 3D illustration

Innovative Strategies for the Discovery of New Therapeutic Targets in Cancer Treatment

This Research Topic highlights novel therapeutic targets for anticancer drug development, focusing on eradicating cancer stem cells using small molecule multitargeting agents and gene therapy-based strategies.

Gynecologist doctor consulting patient showing uterus anatomy model

Evolving Therapies in Gynecological Oncology: From Chemotherapy to Personalized Medicine

This Research Topic aims to explore the evolution from conventional chemotherapy to modern, personalized therapeutic strategies in gynecological oncology.

A tumour sample where the levels of different proteins in cell populations have been identified using a fluorescently labelled antibody

Bladder Cancer Awareness Month 2025: Current Developments and Insights in the Treatment of Bladder Cancer

This Research Topic spotlights advances in bladder cancer diagnosis and treatment aiming to improve outcomes and raise awareness of early detection, innovation, and disparities in care during Bladder Cancer Awareness Month.

Close-up Shot of the Industrial Manufacturing Medical Test Tubes, Process of Sterilising and Filling Items. Sterile High Precision Factory Machinery Producing Items for Medical Use. Abstract Concept.

Precision Oncology: Integrating Molecular Mechanisms, Organoid Models, and Omics Technologies for Personalized Cancer Care

This Research Topic consolidates state-of-the-art insights from molecular biology, high-throughput omics technologies, advanced organoid models, and clinical oncology.

Ovarian cancer cells - isometric view 3d illustration

Recent Advancements in AI-Assisted Gynecologic Cancer Detection

This Research Topic explores AI's role in advancing gynecological oncology, focusing on early cancer detection, cancer risk identification, and personalized treatment strategies to improve patient outcomes.

A tumour sample where the levels of different proteins in cell populations have been identified using a fluorescently labelled antibody

Advances in Meningioma Management and Treatment: Novel Diagnostic Approaches and Emerging Therapeutic Strategies

This Research Topic explores innovative diagnostic and therapeutic strategies for meningiomas, focusing on imaging, molecular profiling, targeted and systemic therapies, and surgical approaches to improve outcomes beyond standard resection.

A macrophage a large white blood cell component of the immune system Absorbs cellular debris pathogens Phagocytosis immune and inflammatory response defense tissue repair 3D scientific render

The Role of RNA Regulation in Cancer Pathogenesis and Therapeutic Strategies

This Research Topic explores the pivotal role of RNA regulation in cancer pathogenesis and its implications for therapeutic strategies, including cancer immunotherapy.

Magnetic resonance venography(MRV) Brain of veins in human head.Medical image too soft and blurry when views full solution.

Reviews in Head and Neck Cancers

This Research Topic features expert reviews on head and neck cancer, covering diagnostics, therapies, immunotherapy, personalized care and rehabilitation, offering key updates to improve outcomes and quality of life for affected individuals.

Fluorescent Imaging immunofluorescence of cancer cells growing in 2D with nuclei in blue, cytoplasm in red and DNA damage foci in green

Leveraging Artificial Intelligence for Biomarker Discovery in Prostate Cancer

This Research Topic explores AI-driven biomarker discovery in prostate cancer, aiming to improve early detection, prognosis, and treatment response.

A group of surgeons performing minimally invasive surgery on the patient's anus using surgical instruments. Surgeons have sterile blue surgical clothing.

Emergency Surgery for Abdominal Cancer: Challenges and Innovation

This Research Topic explores surgical emergencies in oncology, focusing on acute abdominal complications in cancer patients.

Breast Cancer Awareness: Immunohistochemistry for HER2 shows positive cell membrane staining in this infiltrating ductal carcinoma. This patient will benefit for herceptin (trastuzumab) therapy.

Exploring the Breast Tumor Microenvironment: Association to Metastasis, Novel Risk Factors and Novel Treatments and Immunotherapies: Volume II.

This Research Topic compiles the latest information on the biological factors associated with the tumour microenvironment and anti-cancer mechanisms.

Next-Generation Radiotherapy for Prostate Cancer: Precision, Personalization, and Technological Advances

This Research Topic delves into the innovative strategies and technologies that are setting the stage for a new era in prostate cancer radiotherapy.

Human colorectal cancer cells treated with a topoisomerase inhibitor and an inhibitor of the protein kinase ATR (ataxia telangiectasia and Rad3 related), a drug combination under study as a cancer therapy. Cell nuclei are stained blue; the chromosomal protein histone gamma-H2AX marks DNA damage in red and foci of DNA replication in green. Created by Yves Pommier, Rozenn Josse, 2014

National Colorectal Cancer Awareness Month 2025: Current Progress and Future Prospects on Colorectal Cancer Prevention, Diagnosis and Treatment

This Research Topic highlights innovations in colorectal cancer research, including early detection, precision medicine, immunotherapy, and microbiome-based strategies, aiming to advance diagnosis in support of Colorectal Cancer Awareness Month.

Hospital Radiology Room: Multiethnic Woman Standing in Medical Gown in the X-Ray Machine. Adult Female Undergoes Healthcare Exam and is Scanning Chest, Heart, Lungs in Modern Clinic Office.

Advancing Diagnostic Excellence in Early Lung Cancer Detection

This Research Topic highlights diagnostic excellence, which encapsulates achieving an accurate, precise, and timely diagnosis while adhering to the highest standards of patient safety, care, and equity.

T Cells attacking Cancer Cells 3D illustration

National Cancer Research Month 2025: Advances in Detection, Treatment and Therapies in Oncology

This Research Topic provides a platform to spotlight the latest advancements and collaborative efforts that fuel ongoing innovations to improve cancer research and, ultimately, improve patient outcomes and prognosis.

Woman in white robe smiling and looking out the window

Comprehensive Management and Risk Assessment of Breast Cancer-Related Lymphedema: A Multidisciplinary Approach

This Research Topic explores BCRL by investigating risk factors, refining diagnostic approaches, and assessing the efficacy of emerging treatments.

Ribonucleic acid or RNA molecule 3D Rendering. RNA is most often single-stranded 3d rendered.

Transforming Cancer Treatment: The Clinical Potentials of Non-Coding RNAs

This Research Topic explores how ncRNAs can be leveraged to inform clinical decision-making, from diagnostics to therapeutics, with a focus on real-world applications in oncology.

Double helix DNA molecule with modified genes , Correcting mutation by genetic engineering , 3d illustration

Gynecological Cancer Prevention in Women With Inherited Genetic Risk

This Research Topic explores pathogenic mutations linked to gynecological cancer risk, focusing on carrier identification, preventive strategies, and management of high-risk individuals, as well as genetic influences on anticancer drug response.

human female ovary 3D

Evidence-Based Implementation of Innovations in Gynecological Oncology

This Research Topic highlights key advancements, challenges, and the role of collaborative expertise in transforming gynaecologic oncology care.

This Centers for Disease Control and Prevention (CDC) scientist was loading patient samples into an automated instrument, used to test the samples for SARS-CoV-2 antibodies - a sign of past infection by the virus that causes COVID-19 - using the CDC serologic test.

Real-World Clinical and Translational Research in Gastrointestinal Cancers

This Research Topic highlights real-world clinical and translational studies in GI cancers, with a focus on rare tumors and innovative methods like AI, organoids, and metabolomics to inform treatment decisions beyond traditional RCT evidence.

Cancer cells can migrate to other body tissues or organs building metastasis. 3D illustration

Innovative Strategies for the Discovery of New Therapeutic Targets in Cancer Treatment

This Research Topic highlights novel therapeutic targets for anticancer drug development, focusing on eradicating cancer stem cells using small molecule multitargeting agents and gene therapy-based strategies.

Gynecologist doctor consulting patient showing uterus anatomy model

Evolving Therapies in Gynecological Oncology: From Chemotherapy to Personalized Medicine

This Research Topic aims to explore the evolution from conventional chemotherapy to modern, personalized therapeutic strategies in gynecological oncology.

A tumour sample where the levels of different proteins in cell populations have been identified using a fluorescently labelled antibody

Bladder Cancer Awareness Month 2025: Current Developments and Insights in the Treatment of Bladder Cancer

This Research Topic spotlights advances in bladder cancer diagnosis and treatment aiming to improve outcomes and raise awareness of early detection, innovation, and disparities in care during Bladder Cancer Awareness Month.

Close-up Shot of the Industrial Manufacturing Medical Test Tubes, Process of Sterilising and Filling Items. Sterile High Precision Factory Machinery Producing Items for Medical Use. Abstract Concept.

Precision Oncology: Integrating Molecular Mechanisms, Organoid Models, and Omics Technologies for Personalized Cancer Care

This Research Topic consolidates state-of-the-art insights from molecular biology, high-throughput omics technologies, advanced organoid models, and clinical oncology.

Ovarian cancer cells - isometric view 3d illustration

Recent Advancements in AI-Assisted Gynecologic Cancer Detection

This Research Topic explores AI's role in advancing gynecological oncology, focusing on early cancer detection, cancer risk identification, and personalized treatment strategies to improve patient outcomes.

A tumour sample where the levels of different proteins in cell populations have been identified using a fluorescently labelled antibody

Advances in Meningioma Management and Treatment: Novel Diagnostic Approaches and Emerging Therapeutic Strategies

This Research Topic explores innovative diagnostic and therapeutic strategies for meningiomas, focusing on imaging, molecular profiling, targeted and systemic therapies, and surgical approaches to improve outcomes beyond standard resection.

A macrophage a large white blood cell component of the immune system Absorbs cellular debris pathogens Phagocytosis immune and inflammatory response defense tissue repair 3D scientific render

The Role of RNA Regulation in Cancer Pathogenesis and Therapeutic Strategies

This Research Topic explores the pivotal role of RNA regulation in cancer pathogenesis and its implications for therapeutic strategies, including cancer immunotherapy.

Magnetic resonance venography(MRV) Brain of veins in human head.Medical image too soft and blurry when views full solution.

Reviews in Head and Neck Cancers

This Research Topic features expert reviews on head and neck cancer, covering diagnostics, therapies, immunotherapy, personalized care and rehabilitation, offering key updates to improve outcomes and quality of life for affected individuals.

Fluorescent Imaging immunofluorescence of cancer cells growing in 2D with nuclei in blue, cytoplasm in red and DNA damage foci in green

Leveraging Artificial Intelligence for Biomarker Discovery in Prostate Cancer

This Research Topic explores AI-driven biomarker discovery in prostate cancer, aiming to improve early detection, prognosis, and treatment response.

A group of surgeons performing minimally invasive surgery on the patient's anus using surgical instruments. Surgeons have sterile blue surgical clothing.

Emergency Surgery for Abdominal Cancer: Challenges and Innovation

This Research Topic explores surgical emergencies in oncology, focusing on acute abdominal complications in cancer patients.