RNA regulation is a crucial component in the physiological activities within cells, intertwined with processes involving transcription factors and post-translational protein modifications. Disruption in RNA integrity can lead to anomalies in cell growth, maturation, and immune system functioning, creating conditions conducive to cancer development, growth, and proliferation. Recently, the identification of novel RNA regulatory molecules, such as Regnase (Regulatory RNase or MCP-1 induced protein, MCPIP), has illuminated their significant roles within these processes. Additionally, non-coding RNAs have been identified as key contributors to cancer development, providing new avenues for therapeutic intervention, especially in the area of cancer immunotherapy.
This Research Topic aims to explore the pivotal role of RNA regulation in cancer pathogenesis and its implications for therapeutic strategies, including cancer immunotherapy. The main objectives include answering key questions about the mechanisms through which RNA deregulation contributes to cancer, assessing the therapeutic potential of targeting RNA regulatory pathways and non-coding RNA molecules, and testing hypotheses concerning the role of RNA regulators such as Regnase in cancer progression. By exploring these dimensions, the goal is to deepen our understanding of RNA's impact on cancer and uncover novel therapeutic avenues.
To gather further insights in the intersections of RNA regulation, cancer pathogenesis, and treatment approaches, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of RNA deregulation in cancer
- The role of non-coding RNA in modulating cancer immunity
- Therapeutic potential of targeting RNA pathways
- Contributions of Regnase and other RNA regulators in cancer immunomodulation
- RNA-based therapeutic strategies
- Clinical implications of RNA regulation in oncology and immunotherapy
We also encourage submissions of original research, review articles, case studies, and perspectives that contribute to this vibrant field of research.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public omics databases that are not supplemented by relevant functional validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords: TFL, Regnase, MCPIP, non-cording RNA, micro RNA, CART, cancer, cytokine regulation, immunotherapy
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
