Frontiers journals are at the top of citation and impact metrics

This article is part of the Research Topic

Perspectives in Zebrafish Research

Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell Dev. Biol. | doi: 10.3389/fcell.2018.00174

Hematopoietic cytokine gene duplication in zebrafish erythroid and myeloid lineages

  • 1Institute of Molecular Genetics (ASCR), Czechia

Hematopoiesis is precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish has yielded two paralogs of many important genes and genes involved in hematopoiesis. Importantly, these duplication events brought an increased level of complexity in such cases, where both ligands and receptors have been duplicated in parallel. Therefore, precise understanding of binding specificities between duplicated ligand-receptor signalosomes as well as the understanding of their differential expression provides​ an important basis for future studies to better understand the role of duplication of these genes. However, although many recent studies in the field have partly addressed functional redundancy or sub-specialization of some of those duplicated paralogs, this information remains to be scattered over many publications and unpublished data. Therefore, the focus of this review is to provide an overview of recent findings in the zebrafish hematopoietic field regarding activity, role, and specificity of some of the hematopoietic cytokines with emphasis on crucial regulators of the erythro-myeloid lineages.

Keywords: Zebrafish (Danio rerio), Hematopoiesis, cytokine, genome duplication, Myelopoiesis, Erythropoiesis

Received: 26 Sep 2018; Accepted: 06 Dec 2018.

Edited by:

Eirini Trompouki, Max-Planck-Institut für Immunbiologie und Epigenetik, Germany

Reviewed by:

Jill De Jong, University of Chicago, United States
Valerie Wittamer, Free University of Brussels, Belgium  

Copyright: © 2018 Oltova, Svoboda and Bartunek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Petr Bartunek, Institute of Molecular Genetics (ASCR), Prague, Czechia,