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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2018.00378

Discovering RNA-based regulatory systems for Yersinia virulence

 Vanessa Knittel1, Ines Vollmer1, Marcel Volk2 and  Petra Dersch1*
  • 1Department of Molecular Infection Biology, Helmholtz-Zentrum für Infektionsforschung (HZI), Germany
  • 2Zentrum für Individualisierte Infektionsmedizin, Helmholtz-Zentrum für Infektionsforschung (HZI), Germany

The genus Yersinia includes three human pathogenic species, Yersinia pestis, the causative agent of the bubonic and pneumonic plague, and enteric pathogens Y. enterocolitica and Y. pseudotuberculosis that cause a number of gut-associated diseases. Over the past years a large repertoire of RNA-based regulatory systems has been discovered in these pathogens using different RNA-seq based approaches. Among them are several conserved or species-specific RNA-binding proteins, regulatory and sensory RNAs as well as various RNA-degrading enzymes. Many of them were shown to control the expression of important virulence-relevant factors and have a very strong impact on Yersinia virulence. The precise targets, the molecular mechanism and their role for Yersinia pathogenicity is only known for a small subset of identified genus- or species-specific RNA-based control elements. However, the ongoing development of new RNA-seq based methods and data analysis methods to investigate the synthesis, composition, translation, decay and modification of RNAs in the bacterial cell will help us to generate a more comprehensive view of Yersinia RNA biology in the near future.

Keywords: RNA thermometer, RNA Stability, RNA processing, Csr/Rsm system, Virulence, gene regulation, small regulatory RNAs

Received: 31 Jul 2018; Accepted: 05 Oct 2018.

Edited by:

Matthew S. Francis, Umeå University, Sweden

Reviewed by:

Kai Papenfort, Ludwig-Maximilians-Universität München, Germany
Satish Raina, Gdańsk University of Technology, Poland
Erik Holmqvist, Uppsala University, Sweden  

Copyright: © 2018 Knittel, Vollmer, Volk and Dersch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Petra Dersch, Helmholtz-Zentrum für Infektionsforschung (HZI), Department of Molecular Infection Biology, Braunschweig, 38124, Germany, petra.dersch@helmholtz-hzi.de