Interference with quorum-sensing signal biosynthesis as a promising therapeutic strategy against multidrug-resistant pathogens
- 1Programa de Pós-graduação em Patologia Molecular, Universidade de Brasília, Brazil
- 2Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brazil
- 3Porto Reports, Brazil
- 4S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Brazil
- 5Massachusetts Institute of Technology, United States
- 6Broad Institute of MIT and Harvard, United States
- 7The Center for Microbiome Informatics and Therapeutics, United States
Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance.
Keywords: Virulence, Quorum Sensing, Quorum-sensing Inhibition, antibiotic resistance, anti-virulence therapy
Received: 21 Aug 2018;
Accepted: 12 Dec 2018.
Edited by:Rodolfo García-Contreras, National Autonomous University of Mexico, Mexico
Reviewed by:Hanne Ingmer, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Yael González Tinoco, Ensenada Center for Scientific Research and Higher Education (CICESE), Mexico
Copyright: © 2018 Fleitas, Rigueiras, Pires, Porto, Silva, de la Fuente and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Dr. César de la Fuente, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, United States, firstname.lastname@example.org
Prof. Octavio L. Franco, Universidade Católica de Brasília, Centro de Análises Proteômicas e Bioquímicas, Brasília, 71966-700, Brazil, email@example.com