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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2019.00294

Patients with LR-HPV infection have a distinct vaginal microbiota in comparison with healthy controls

 Yunying Zhou1*,  Lu Wang1, Fengyan Pei1, Mingyu Ji1, Yingshuo Sun1, Fang Zhang1,  Qianqian Zhao1, Yatian Hong1, Xiao Wang1, Juanjuan Tian1 and Yunshan Wang1
  • 1Medical Research Laboratory Diagnostic Center, China

Condyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV) which has already occupied the second most common viral sexually transmitted infections (STIs) in China. 90% of CA patients are caused by the low-risk HPV 6 and 11. Except low-risk HPV infection there are likely other factors within the local microenvironment that contribute to CA and there has related articles so far. In this study, 62 vaginal specimens were analyzed using 16S rRNA gene sequencing. The diversity of the vaginal microbiota was higher and the composition was different with LR-HPV infection. While the relative abundance of dominant Firmicutes was lower, Actinobacteria, Proteobacteria and Fusobacteria phyla were significantly higher; at the genus level Gardnerella, Bifidobacterium, Sneathia, Hydrogenophilus, Burkholderia and Atopobium were higher. This study firstly confirmed a more accurate and comprehensive understanding of the relationship between low-risk HPV infection and vaginal microbiota, in order to provide a theoretical basis for further research on the occurrence and development of CA.
Keywords: Low-risk HPV, Condyloma acuminatum, vaginal microbiome, 16S rRNA sequencing

Keywords: low-risk HPV, vaginal microbiome, Condyloma acuminatum, 16S rRNA sequencing, HPV – human papillomavirus

Received: 01 Mar 2019; Accepted: 30 Jul 2019.

Edited by:

Eric C. Martens, University of Michigan, United States

Reviewed by:

Nick Wheelhouse, Edinburgh Napier University, United Kingdom
Christine Bassis, University of Michigan, United States  

Copyright: © 2019 Zhou, Wang, Pei, Ji, Sun, Zhang, Zhao, Hong, Wang, Tian and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yunying Zhou, Medical Research Laboratory Diagnostic Center, Jinan Shandong Province, China, joan0539@163.com