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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2019.00394

Dogs as new hosts for the emerging zoonotic pathogen Anaplasma capra in China

 Changshen Ning1*, Ke Shi1,  Junqiang Li1, Yaqun Yan1, Qian Chen1, Kunlun Wang1,  Yongchun Zhou1,  Dongfang Li1,  Yuancai Chen1, Fuchang Yu1, Yongshuai Peng1 and Longxian Zhang1
  • 1Henan Agricultural University, China

Anaplasma capra is an emerging zoonotic tick-borne pathogen with a broad host range including the ticks and many mammals. Dogs as primary companion not only have a close relationship with humans but also regularly contact with the external environment. Moreover, dogs had been reported as hosts of A. phagocytophilum, A. platys, A. ovis, and A. bovis. To confirm whether dogs are also A. capra hosts, pathogens DNA from 521 dogs blood samples were extracted, followed by PCR amplification of the A. capra citrate synthase gene (gltA), heat shock protein gene (groEL), and major surface protein 4 gene (msp4). A. capra was identified in 63 specimens. No significant difference were observed between genders (P = 0.578) and kinds (P = 0.154). Risk factor analysis showed that significantly high A. capra infections occurred dogs contact with vegetation (P = 0.002), aged over 10 years (P = 0.040), and during the summer season (P =0 .006). Phylogenetic analysis based on gltA, groEL, and msp4 demonstrated that isolates obtained in this study were clustered within the clade inside A. capra, but were distinct from other Anaplasma spp. In conclusion, dogs have been documented as hosts of the human pathogenic A. capra. Considering the affinity between dogs and humans and the zoonotic nature of A. capra, dogs should be carefully monitored for the presence of ticks.

Keywords: Anaplasma capra, Dogs, hosts, Tick-borne, Zoonotic

Received: 19 Jul 2019; Accepted: 04 Nov 2019.

Copyright: © 2019 Ning, Shi, Li, Yan, Chen, Wang, Zhou, Li, Chen, Yu, Peng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Changshen Ning, Henan Agricultural University, Zhengzhou, China,