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ORIGINAL RESEARCH article

Front. Digit. Health, 15 September 2025

Sec. Health Technology Implementation

Volume 7 - 2025 | https://doi.org/10.3389/fdgth.2025.1611225

This article is part of the Research TopicImplementing Digital Twins in Healthcare: Pathways to Person-Centric SolutionsView all 8 articles

Evaluating CFIR 2.0 in identifying digital twin implementation challenges in healthcare: bridging the dichotomy between engineering and healthcare communities


Md Doulotuzzaman Xames
Md Doulotuzzaman Xames1*Taylan G. TopcuTaylan G. Topcu1Sarah H. ParkerSarah H. Parker2Vivian ZagareseVivian Zagarese2John W. Epling
John W. Epling3
  • 1Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, United States
  • 2Department of Health Systems and Implementation Science, Virginia Tech Carilion School of Medicine, Roanoke, VA, United States
  • 3Department of Family and Community Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA, United States

Background: Digital twin (DT) technology holds significant promise for healthcare systems (HSs) due to real-time monitoring based on streaming operational data and a priori analysis capabilities without interrupting clinical workflows. However, the sociotechnical complexity of HSs presents challenges for effective DT implementation. A dichotomy also exists between the engineering and implementation science (IS) communities regarding DT implementation challenges. This study assesses the efficacy of the updated Consolidated Framework for Implementation Research (CFIR 2.0) in identifying DT implementation challenges, aiming to bridge the knowledge gap between IS and DT communities.

Methods: This study presents findings from a DT implementation case study in a family medicine clinic, an operational healthcare microsystem. It adopts CFIR 2.0 to guide semi-structured interviews with four key stakeholder groups (e.g., family medicine specialists, engineers, organizational psychologists, and implementation scientists). Participants (N = 8) were purposively sampled based on their roles in DT implementation. Thematic coding categorized interview data into seven themes: technological, data-related, financial and economic, regulatory and ethical, organizational, operational, and personnel. Thematic data were then cross-analyzed with challenges documented in DT literature to assess how effectively CFIR 2.0 identifies DT implementation challenges.

Results: Challenges were grouped into three categories: (i) shared challenges captured by both IS and DT communities, (ii) CFIR 2.0-identified challenges overlooked in DT literature, and (iii) challenges documented in DT research but not captured through CFIR 2.0-guided interviews. While there was strong overlap between the communities, a formidable gap also remains. CFIR 2.0 effectively identified a diverse set of issues—predominantly in organizational, financial, and operational themes—including many overlooked by the DT community. However, it was less effective in capturing technological and data-related barriers critical to DT performance, such as modeling, real-time synchronization, and sensor reliability.

Conclusions: CFIR 2.0 effectively identifies organizational and operational barriers to DT implementation in healthcare but falls short in addressing technological and data-related complexities. This study highlights the need for interdisciplinary collaboration for the successful transition of emerging DT technologies into practice to maximize their impact on HS efficiency and patient outcomes.

1 Introduction

Healthcare systems (HSs) and organizations regularly invest significant financial, technical, and clinical resources into interventions (e.g., new technologies, processes, guidelines) that are aimed at improving care quality and organizational efficiency (1, 2). Nevertheless, a high-quality, evidence-based intervention does not ensure the expected benefits will be realized. Accurate modeling of HSs with explicit consideration of the downstream impact of interventions on daily workflows could facilitate smoother implementation; however, this is challenging due to the inherent complexity of HSs (35) and the involvement of human actors at multiple levels (6, 7). Traditional simulations, while useful (8), are time-consuming, resource-intensive, and often fail to capture the dynamic nature of real clinical settings (9, 10). Additionally, policy recommendations generated by traditional simulations do not offer a direct implementation interface into HS operations (11) and their realization is often hindered by sociotechnical barriers (1214). To that end, emerging digital twin (DT) technology bears great promise (1517).

DTs offer a compelling alternative to traditional modeling and simulation-based approaches by integrating virtual representations of physical entities with real-time operational data and automated reasoning capabilities (18, 19), enabling continuous and real-time updates (20, 21). Using DTs, HSs could rigorously test new interventions in a low-risk virtual environment without disturbing daily operations and identify associated implementation risks a priori. This approach could enhance healthcare leaders' and frontline staff's understanding of the impact of an intervention before implementation. Ultimately, DTs could support the Quintuple Aim (22) as they are documented to enhance predictive accuracy, minimize intervention delays, and inform decisions that could concurrently improve the quality of care (23), provider well-being (24), health equity (25), efficiency of operations (26), and HS sustainability (27).

However, the intricate and dynamic nature of HSs—driven by the complex interplay between biological processes, human decision-making, and technology—presents unique challenges for implementing DTs into HSs effectively (16). Given the expected widespread adoption of DTs (16), identifying these challenges within the healthcare setting is crucial. Nevertheless, a dichotomy exists in the literature regarding the documentation of these challenges, specifically between the Implementation Science (IS) community and the engineering community that has been leading the development of DTs.

The IS community recognizes the sociotechnical complexity of HSs and relies on comprehensive frameworks, such as the Consolidated Framework for Implementation Research (CFIR) (28), to identify implementation barriers (2931). Although CFIR is mainly used for clinical interventions, its application to technological interventions, like DTs, is still nascent (3234); and it remains to be seen whether it could facilitate the implementation of DTs into practice. Meanwhile, the engineering community that has been spearheading the development of DTs is predominantly concerned with maturing the technology and currently overlooks implementation concerns, particularly those related to the unique contextual setting of HSs. Our objective is to assess CFIR's effectiveness and identify opportunities for knowledge transfer between IS and DT communities. To that end, documenting knowledge gaps between IS and DT research is crucial for expediting DT adoption. This paper addresses this problem at its core by addressing the following research questions (RQs):

 RQ1: How effective is CFIR 2.0 in identifying DT implementation challenges in HSs?

 RQ2: What are the knowledge gaps between the IS and engineering communities on DT implementation, and how can they be bridged?

We explore these questions using a representative DT case study on provider workload in an operational HS microsystem, a family medicine clinic. We used CFIR 2.0 (35) to extract data on DT implementation challenges from key HS stakeholders. We then compare CFIR 2.0 findings with implementation challenges that are currently documented in the engineering literature. We find that CFIR is effective in identifying numerous implementation barriers, including novel ones that are currently overlooked by the engineering community. However, several significant challenges that relate to modeling, connectivity, data fusion, and lifecycle management remained undetected in our case study, despite including key stakeholders from all relevant disciplines. Findings reveal the multifaceted nature of these implementation challenges and the critical role of details in successful DT implementation in HS operations. We discuss how a more integrated approach between these communities could support the implementation process and improve related outcomes.

2 Literature review

2.1 Digital twins in healthcare systems

Although specific definitions vary based on the application area, a DT could be defined as the combination of a physical system, its virtual representation, and the bilateral data and information flow linking these two (36). Over the past two decades, advances in artificial intelligence (AI), machine learning (ML), and the Internet of Things (IoT) have driven the growth of DT research (19), enabling capabilities like system health monitoring (37), anomaly detection (38), and predictive maintenance (39). While DT applications are used in increasingly more diverse sectors, they are most prevalent in engineering fields such as manufacturing, civil, and aerospace (40).

DT research for HSs has grown rapidly in recent years, focusing primarily on improving patient care (16, 41, 42). A recent systematic review categorizes this body of research into four HS contexts: the patient's body, medical procedures, facilities, and public health (16). DTs within the context of a patient's body are used for monitoring health (43), early diagnosis of diseases (44), aiding rehabilitation (45); and providing personalized treatment by managing biological processes in cells (46) and organs (47), as well as supporting precision medicine through augmented intelligence and patient-specific modeling approaches (48, 49). In terms of medical procedures, DTs are developed to govern medical robots for precision surgery (50), advanced sensors for data collection (51), and wearable exoskeletons for monitoring (52). Similarly, DTs are leveraged to assist robotic surgeries (53, 54), dental procedures (55), and other surgical decision-making (56). In the context of healthcare facilities, DTs enhance operations of hospitals in general (57, 58) or specific HS units such as emergency departments (59, 60) through improved staff scheduling (61) and workflow optimization (60). Other applications include remote patient monitoring (62), mental health management (63), drug development and testing (64), public health management (23), and pandemic monitoring (65).

Nevertheless, the vast majority of this research remains conceptual, and research on successful DT integration into HS practice is nascent (16). This is concerning given the lackluster history of technology implementation in HSs, such as in the case of EHR (66, 67), and the complex socio-technical interactions that constitute HS operations (3, 68). These concerns also motivate this study.

2.2 Implementation science frameworks

The Implementation Science (IS) community offers numerous frameworks to guide researchers and practitioners in the adoption, integration, and evaluation of evidence-based interventions in healthcare settings (69). Frameworks like the CFIR (28), the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) (70), the Promoting Action on Research Implementation in Health Services (PARiHS) (71), the Ecological framework, and the Non-Adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework (72) offer comprehensive lenses to analyze the intertwined factors influencing intervention success (69). These frameworks emphasize the dynamic interplay between the organizational context, external environment, and individual stakeholder attributes, and the interaction of these with intervention characteristics. For example, the CFIR organizes these factors into five domains, offering a structured approach to identifying barriers and facilitators. Similarly, RE-AIM focuses on evaluating the public health impact of interventions by assessing reach, effectiveness, adoption, implementation fidelity, and long-term maintenance, making it particularly useful for balancing internal and external validity.

Here, it is useful to emphasize that these frameworks are not mutually exclusive but rather complementary in terms of addressing different implementation challenges. For instance, the PARiHS highlights the role of evidence, context, and facilitation in driving successful implementation, making it particularly useful in healthcare settings where stakeholder engagement and organizational readiness are critical (73). On the other hand, the NASSS addresses the complexity of scaling health technologies by examining domains such as the condition being treated, the technology itself, and the wider socio-political context, providing insights into why interventions may fail or succeed in real-world scenarios (74). Synergistic use of these frameworks could lead to a more holistic understanding of the factors influencing implementation, enabling to design of implementation strategies that are effective, adaptable, and sustainable in diverse settings (75).

CFIR is a framework designed to identify key factors influencing the implementation of healthcare interventions. It is structured around five domains: intervention characteristics, outer setting, inner setting, characteristics of individuals, and the implementation process. Each of these domains encompasses a wide range of constructs that shape how interventions are adopted, implemented, and sustained within HSs. For instance, in the inner setting domain, constructs such as culture, structural characteristics, and mission alignment can significantly impact the successful adoption of an intervention in a facility. CFIR is often regarded as a suitable framework for assessing complex technology implementation (76, 77).

CFIR 2.0, the framework used in this study, is an updated version of CFIR that refines existing constructs and introduces new ones to better address the complexities of healthcare intervention implementation, particularly in the context of technology adoption. Compared to CFIR, CFIR 2.0 offers a more nuanced understanding of contextual factors, such as the dynamic interplay between organizational culture and external policies, as well as a stronger emphasis on stakeholder engagement and the integration of emerging technologies like digital health tools (35). By doing so, CFIR 2.0 provides a more robust and flexible framework for examining implementation challenges associated with complex interventions such as digital health technologies in healthcare environments (78, 79).

Ideally, an evidence-based intervention in healthcare would be tested in a controlled setting, with variables that are well-defined and vary consistently. While early iterations of DTs may have just these qualities, within healthcare applications, the utility of a DT will be maximized in its ability to mirror the complexity and dynamic nature of HSs. Thus, context is imperative for both accurate DT development and for identifying useful interventions.

With this perspective in mind, we explored appropriate implementation frameworks. There are extensive reviews on the variety and purpose of different implementation frameworks (32, 33, 69). Since the purpose of this study is to describe the process of translating DTs into practice, we are interested in preemptively determining which factors might influence implementation outcomes, such as feasibility, acceptability, adoption, etc. To that end, CFIR 2.0 provides a comprehensive, adaptable structure that articulates relevant factors at different levels in an operational context. CFIR 2.0 examines interactions across five domains, offering a holistic view of implementation dynamics. Further, since it clearly defines and labels the constructs that describe the contextual factors, it could help identify barriers and facilitators for implementation, making it suitable for DT development and implementation (80).

2.3 The research gap

Despite DTs' emerging potential, the research on their effective integration into HSs is nascent (16, 81). DTs are inherently complex technologies that encompass interconnected processes, including data collection, real-time processing, predictive analytics, and intelligent decision-making. These multifaceted capabilities make their implementation in healthcare particularly challenging, requiring a structured approach to navigate technical, organizational, and contextual barriers. At the same time, DTs are complex technologies that span data collection, processing, and intelligent decision-making capabilities. However, there is a lack of evidence regarding how and to what extent existing IS frameworks can help identify DT implementation challenges in healthcare. For instance, so far, there has been only one study that explored this issue (82) that used the NASSS framework (72) in the context of cardiovascular medicine DT. However, while valuable, this study is limited to literature-based evidence and did not incorporate a case study of DT implementation to understand the complexities of daily HS operations. Thus, there is an opportunity to strengthen the connection between the implementation challenges with the broader challenges identified in the engineering community. To address this gap, we explore the applicability of CFIR 2.0 in identifying DT implementation challenges through a real-world case study in a relevant HS context: a family medicine clinic—a critical component of the U.S. healthcare system that serves as the first point of contact for many patients and is often burdened by high workloads (83). We then contrast our findings with the DT literature to highlight knowledge gaps and transfer opportunities.

3 Materials and methods

3.1 Research methodology

Figure 1 outlines our approach, which leverages our healthcare DT implementation case study (24), the CFIR 2.0 framework, and a comprehensive evaluation of the DT literature to identify implementation challenges. Our qualitative approach incorporates stakeholder interviews while maintaining reflexivity, and the research paradigm aligns with constructivism/interpretivism. Below, we elaborate on our framework and discuss the case study in Section 3.2.

Figure 1
Flowchart depicting steps for analyzing Digital Twin (DT) implementation challenges using CFIR 2.0. Steps include selecting a case study, identifying stakeholders, conducting interviews, synthesizing data, reviewing literature, and comparing challenges. The comparison identifies shared challenges and knowledge transfer opportunities, with outcomes categorized into challenges addressed by both CFIR 2.0 and DT literature, challenges addressed only by CFIR 2.0, and those only by DT literature.

Figure 1. Research framework used in this study.

In Step 1, we present the DT case study and the operational setting in which the technology implementation will be executed. In Step 2, we followed CFIR 2.0 guidance to identify the key stakeholders that have significant expertise and influence over both HS operations and implementation outcomes. In our case, four distinct groups of stakeholders were: organizational psychologists, implementation scientists, engineers, and family medicine specialists.

In Step 3, we conducted interviews with these stakeholders, discussing the specifics of the DT we are aiming to implement. Following a structured protocol guided by the 39 constructs of CFIR 2.0, each of the interviewees was asked to identify the challenges given their specific role in the organization.

In Step 4, we synthesized the interview data and aggregated them through a deduplication process, resulting in a comprehensive set of challenges as identified by the experts.

In Step 5, we complemented these CFIR 2.0-guided findings through a synthesis of the literature on DT research and extracted data on DT implementation challenges. In Step 6, we synthesized the extracted data from the DT literature to identify unique implementation challenges.

Finally, in Step 7, we performed a cross-comparative analysis between the two sets of challenges identified: those obtained from HS stakeholders following CFIR 2.0 guidance and those synthesized from the DT literature. This analysis revealed three distinct groups of challenges: (i) shared challenges that are captured by both CFIR 2.0 and the DT literature, (ii) challenges identified through CFIR 2.0 but not actively considered in the DT literature, and (iii) challenges addressed in the DT literature but were not revealed by our experimental usage of CFIR 2.0. We consider the first group as shared knowledge, while the latter two groups represent knowledge that should be transferred bilaterally between the IS and DT research communities to address the ongoing dichotomy. Note that in Figure 1, the bolded text within each category highlights challenges that correspond to specific sources. We present our findings in Section 4.

3.2 Case study and the research setting

3.2.1 The case study: provider workload DT

The case used in this study is a DT to measure and manage provider workload for HSs, with the long-term objective of assisting in burnout mitigation. Burnout in healthcare is a multifaceted issue that undermines providers' mental health, patient care quality, and workforce stability and imposes significant financial costs (81). Thus, effective workload management is key to addressing the root causes of burnout and mitigating its impact (84, 85). While the detailed conceptual model is presented elsewhere (24), a summary is provided here.

This DT facilitates close to real-time monitoring and management of healthcare provider workload. Figure 2 offers a schematic of its structure, comprising three elements. The first element, at the center of the diagram, is a virtual model of physician workload that incorporates an array of data-driven models (e.g., ML, AI). DT generates operational recommendations based on the quantification of physician workload and identifies physicians who are exposed to high risk given their task patterns over time, technological interaction, and human factor concerns. The second component is a physical-to-virtual mapping that feeds streaming operational data into the virtual model. This data flow is indicated by solid arrows in Figure 2. This data is collected from various sources, including sensor and wearable devices worn by providers, operational and clinical data from electronic health records (EHR), and other relevant data from enterprise resource planning (ERP) systems. The third component is a virtual-to-physical mapping interface, translating DT recommendations into HS operations. This interface is overseen by human decision-makers (e.g., managers) and enables the implementation of recommendations through staffing, process planning, and scheduling decisions. In Figure 2, this information flow is indicated by the dotted arrows. Collectively, this DT provides continuous workload assessment and real-time adjustments, allowing healthcare managers to control and manage workload effectively, ultimately preventing provider burnout.

Figure 2
Flowchart depicting a healthcare provider workload model. Data sources include sensor and wearable data from healthcare provider, operational and clinical data from electronic health records, and operational data from enterprise resource planning systems. This data feeds into a

Figure 2. Simplified schematic of the functioning of our representative provider workload DT.

3.2.2 Research setting: An operational family medicine clinic

Primary care facilities are clinical microsystems (86) that play an integral role in the U.S. healthcare system, serving as the first point of contact for most patients and managing a high volume of patient care situations across a wide spectrum of conditions (83, 87). We chose to conduct our study in a family medicine clinic because primary care physicians represent 29.9% of active physicians in the U.S., with 38.8% specializing in family medicine (88), thus constituting a significant portion of care delivery. Further, an estimated 51% of family physicians in 2022 reported being burned out (89), which aligns the setting well with the proposed case study. Within our chosen observation setting, there are over 50 physicians. This sample is carefully chosen to represent a diverse range of demographics and expertise, ensuring that the DTs reflect the varied experiences and challenges faced by providers across different walks of life.

3.2.3 Stakeholder identification and interviews

To capture diverse perspectives on DT implementation challenges in HSs, four key stakeholder groups were selected following systems engineering best practices (90, 91). These groups included engineers, implementation scientists, organizational psychologists, and family medicine specialists, with two participants in each group for purposive sampling. Engineers were included because they are responsible for designing, implementing, and maintaining the DT system. Implementation scientists were selected for their expertise in overseeing and evaluating implementation efforts, ensuring that best practices are followed. Family medicine specialists, as the primary users of the DT system and the focal point of the study, were crucial in providing insights into its real-world applicability and impact on clinical workflows. Organizational psychologists were included to offer perspectives on human factors, behavioral dynamics, and systemic challenges related to the adoption and integration of DTs in healthcare environments.

While the sample size consisted of two participants per stakeholder group (N = 8) and may appear limited in size, this is primarily a concern for studies seeking broad generalizability. In our case, this design was purposefully selected based on the study's focused objective and the contextual constraints of the clinical setting. Empirical work by Hennink & Kaiser (92) suggests that data saturation in qualitative research can often be reached with 9–17 interviews in homogeneous populations. Our participants were deeply embedded in the same organizational context and shared a close understanding of the DT implementation process. Thematic analysis revealed substantial redundancy in responses, indicating that saturation was adequately achieved for our study purpose.

These eight stakeholders were selected not only for their direct involvement in the DT case study but also because they work on-site and have deep firsthand knowledge of the HS's operational intricacies. Their embedded roles within the clinic provided them with a comprehensive understanding of the challenges and facilitators affecting DT implementation. To maintain a focused scope, certain groups were not included in the study. For instance, while nurses play a critical role in patient care, we opted to exclude them because family medicine specialists, who work closely with them, were well-positioned to capture their perspectives as part of the broader clinical workflow. The characteristics of the selected participants are summarized in Table 1 below.

Table 1
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Table 1. Characteristics of the interview participants in our study.

To collect the data, we conducted semi-structured face-to-face interviews guided by CFIR 2.0 constructs, enabling the exploration of specific challenges relevant to each stakeholder group while maintaining consistency across interviews. This approach facilitated the collection of rich, context-specific data from individuals actively involved in HS operations and integral to the DT implementation process.

Data analysis followed a thematic coding approach. Initially, interview transcripts were reviewed independently by two researchers to ensure comprehensive familiarity with the content. Open coding was employed to identify preliminary codes, which were subsequently refined through axial coding to establish overarching themes and sub-themes. To enhance rigor, the researchers engaged in regular debriefing sessions to discuss coding discrepancies and consensus-building discussions to resolve disagreements. To ensure the credibility and trustworthiness of the data analysis, “member checking” was conducted, wherein preliminary findings were shared with participants to verify the accuracy and relevance of the interpretations. This process helped confirm that the identified themes accurately reflected participants’ perspectives. While the data were not blinded during analysis, coders maintained an awareness of potential biases and engaged in reflexive discussions to mitigate their influence.

To enhance transparency and ground the thematic findings, we incorporated illustrative quotes from participants throughout the results section. These quotes were selected based on their clarity, thematic alignment, and stakeholder relevance. We prioritized excerpts that exemplified frequently occurring patterns or provided particularly vivid articulation of a sub-theme. Divergent or conflicting perspectives, such as when stakeholders offered contrasting views on a particular challenge, were coded alongside convergent views and included in the thematic structure without exclusion.

4 Results

In our case study of provider workload DT, we identified a total of 80 implementation challenges through a comprehensive review of DT literature and the CFIR 2.0 framework-guided interviews. We performed a cross-comparative analysis of these datasets, grouping the challenges into three categories, as shown in Figure 3. Of the 80 challenges, 66 were identified through CFIR 2.0-guided interviews (see Supplementary Table 1). Of these, 34 are also recognized in the DT literature. Below is an overview of the findings:

Figure 3
Venn diagram comparing challenges identified through CFIR 2.0-guided interviews and DT literature review. The blue circle represents CFIR-specific challenges with 32 items, the pink circle represents DT literature-specific challenges with 14 items, and the overlapping purple section indicates 34 shared challenges.

Figure 3. A Venn diagram showing the overlap among the challenges.

Shared challenges (n=34): Recognized in both CFIR 2.0-guided interviews and DT literature.

CFIR-specific challenges (n=32): Identified through CFIR 2.0 interviews but overlooked in DT literature, highlighting the need for knowledge transfer from IS to DT research community.

DT literature-specific challenges (n=14): Identified only in DT literature, raising concerns about CFIR 2.0's ability to fully capture DT implementation complexities. These represent knowledge transfer opportunities from DT to IS community.

To render it easier to digest for the broader audience, we organized the 80 challenges into seven overarching themes: technological, data-related, financial and economic, regulatory and ethical, organizational, operational, and personnel. These apply to all three challenge groups thus we provide their definitions below:

i. Technological challenges: Issues with DT development, integration, and scalability.

ii. Data-related challenges: Difficulties in data acquisition, management, quality, and secure exchange across platforms.

iii. Financial and economic challenges: Cost-related barriers, including investment, maintenance, return on investment (ROI) uncertainties, and budget constraints.

iv. Regulatory and ethical challenges: Legal, regulatory, and ethical concerns, such as patient privacy and healthcare compliance.

v. Organizational challenges: Structural and cultural barriers within healthcare institutions.

vi. Operational challenges: Practical challenges in testing, training, and integrating DTs into existing workflows.

vii. Personnel challenges: Human resource-related barriers affecting DT adoption and integration.

Next, we discuss our findings in detail.

4.1 Shared implementation challenges

This section covers overlapping challenges with the DT literature. These challenges, summarized in Table 2, span all seven themes introduced earlier. Here, we note that while some of these challenges appear frequently in DT literature, others—like usability issues, data fragmentation, data governance, and collaboration barriers—are rarely discussed, each appearing in only one reviewed article.

Table 2
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Table 2. DT implementation challenges addressed in DT literature and also identified through CFIR 2.0-guided interviews.

Below, we discuss these shared challenges and their implications for DT implementation in healthcare.

Technological challenges are crucial to DT implementation because they directly impact the functionality, reliability, and integration of the technology within existing systems. Among these, verification and validation issues are critical, as inaccurate DTs lead to poor decision-making (93, 94). Additionally, the lack of standardization across DT frameworks hampers interoperability, creating silos that hinder integration with existing systems (95, 96). For instance, this was echoed in the following stakeholder quotes:

“… Data remains siloed. Scheduling data, provider demographic and wellbeing data, patient outcome data, and EPIC operations data are all separate.”—Family medicine specialist #2.
“… There are several different data platforms that could be needed as inputs and outputs. Aligning these inputs for time and subject consistency is challenging. Likewise, translating the DT outputs back into the non-unified software is challenging.”—Implementation scientist #1.

Usability concerns further exacerbate this fragmentation, particularly for non-technical users (97). Interoperability and infrastructure integration issues may require substantial organizational overhauls (98, 99). Furthermore, testing and evaluation concerns are particularly challenging, making it difficult to assess the accuracy and reliability of DTs in real-world conditions (100). Performance issues, particularly in scalability and real-time processing, highlight the gap between the theoretical potential of DTs and their practical implementation (101, 102). Addressing these diverse technological challenges is critical for ensuring DTs can reliably be integrated into HS and enhance healthcare outcomes.

Data-related challenges are intrinsically linked to the successful implementation of DTs, as their efficacy is contingent upon the availability and quality of data. The demand for massive real-time data inputs applies significant pressure on HSs, which may not be readily equipped with a suitable data infrastructure to supply the necessary demand (82, 109).

“… To accurately represent the complex human-system interactions, a very large amount of data over a long period of time must be included in the initial model build.”—Engineer #1.

Moreover, the fusion of disparate data sources presents additional challenges that can undermine the coherence of DT outputs (105, 110). Data accessibility is another issue that is often exacerbated by proprietary software, security controls, and organizational silos (108).

“… Accessible data limits the ability of the digital twin to consider the relationship between insurance benefits and regulatory considerations (including publicly reported measures such as LeapFrog, U.S. News, and CMS Five-Star program) with the healthcare delivery entity.”—Family medicine specialist #1.

Perhaps the most concerning are the challenges related to data privacy and security. HSs inherently deal with sensitive information and are particularly vulnerable to data breaches, making robust security measures non-negotiable (113, 114). Effective data governance and clear ownership protocols are essential to mitigate associated risks and ensure accountability (20, 105).

Financial and economic challenges present another barrier, particularly the high initial costs of DT deployment, which include software, hardware, and skilled personnel. This burden could be particularly daunting for small and medium-sized healthcare organizations (82, 115). This financial burden is compounded by the uncertainty surrounding the ROI, which can deter organizations from committing to DT investments.

“… The technology should improve operations and thus pay for itself. Without clear financial returns, the willingness of healthcare organizations to invest remains uncertain.”—Organizational scientist #2.

Regulatory and ethical challenges are critical to DT implementation and need to be considered proactively as they can lead to legal repercussions, compromised patient safety, and loss of public trust. Legal issues such as liability and intellectual property rights raise significant concerns, particularly when decisions will be directly based on DT outputs without human intervention (41, 116). Ethical concerns demand careful consideration, including potential biases in algorithmic decision-making and the broader societal implications of DTs such as equitable access to technology. These issues can lead to serious consequences, such as misdiagnoses or inappropriate treatment plans if not rigorously addressed (25, 118). For example, biases in algorithmic decision-making could result in unequal treatment recommendations across different patient demographics, undermining trust in the technology and the broader HS. Additionally, failure to comply with regulatory standards can result in legal repercussions and damage public trust, rendering healthcare providers and patients reluctant to adopt these technologies (23, 109).

Organizational challenges are frequently overlooked but influence the success of implementation efforts. Organizational inertia, or resistance to change, is a formidable barrier to the adoption of DTs (100).

“… The current state is well-established and unlikely to change without significant external pressure.”—Organizational scientist #1.

This resistance is often rooted in the “fear of the unknown” and concerns about the disruption of established workflows. Additionally, the organizational readiness to adopt new technologies, including the necessary IT infrastructure and culture, is crucial for successful DT implementation (124). Collaboration and communication barriers further complicate this process, as the successful deployment of DTs often requires cross-disciplinary cooperation, which is difficult to achieve in siloed environments (125).

Operational challenges reflect the day-to-day realities of implementing DTs in healthcare. Lack of training and support infrastructure hinders effective use, especially in organizations new to DT technologies (41).

Building trust in DTs is another operational challenge, particularly given the high stakes associated with clinical decision-making (113). In healthcare settings, errors stemming from model misjudgments can have serious consequences for patient safety and outcomes. Therefore, transparency into how DTs generate outputs is not just a technical concern but a critical trust-building mechanism for clinicians and administrators. However, this transparency is notoriously difficult to establish for most ML and AI-based models, which often operate as “black boxes” (127). Importantly, ensuring that DTs are positioned as tools that augment rather than replace clinical judgment is essential for promoting trust and acceptance among providers (48). Moreover, quantifying the benefits and outcomes of DT deployment is also crucial for ongoing support, yet difficult to measure reliably (123).

Finally, personnel challenges are human resources-related barriers that primarily revolve around the availability, expertise, and attitudes of personnel responsible for deploying and maintaining these systems. The specialized skills required for successful DT implementation are scarce, making it difficult to find and retain talent (101). Moreover, similar to most healthcare interventions, the success of DT projects is closely tied to the commitment of individuals within the organization, particularly those in leadership or key technical roles (126).

“… Key stakeholders essential for validation and implementation may be reluctant to dedicate their own time or their team's time to testing, troubleshooting, and deployment, hindering the implementation process.”—Implementation scientist #2.

Perceptions of DT technology among healthcare providers further compound these challenges. Technophobia, especially among older staff, can significantly hinder DT adoption (103). This may be influenced by previous personal experiences with new technology implementation in healthcare, such as EHR, which is often perceived as challenging and negative (128130). Additionally, fears of added workload and resistance to change are common in environments where established operational practices are deeply ingrained (82, 100). A lack of understanding of DTs could exacerbate these issues, leading to mistrust and reluctance to engage (41). Addressing these personnel challenges is crucial for ensuring that DTs are not only technically successful but also fully embraced and sustained by the people who will use them.

4.2 Knowledge transfer from IS community to DT research community

Our CFIR 2.0-guided interviews with key stakeholders revealed 32 novel challenges that are not currently addressed in the DT literature. These challenges encompass all categories except data-related issues, with organizational challenges being more common, accounting for nearly half (n = 15) of the identified problems. This likely reflects the insights of stakeholders directly involved in the implementation process, including organizational psychologists, implementation scientists, and family medicine specialists; that are often overlooked within the engineering community during early-stage technology maturation and treated as a later-stage consideration. Detailed in Table 3, these challenges highlight factors that could affect the successful DT implementation, emphasizing the need for knowledge transfer from the IS community to the DT community. Below, we elaborate on these challenges. Notably, no new data-related or regulatory and ethical challenges emerged from the CFIR 2.0-guided interviews.

Table 3
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Table 3. DT implementation challenges identified through CFIR 2.0-guided interviews, however, not addressed in DT literature.

Technological challenges such as time-scale dependencies, model latency, and personalization illustrate the nuanced complexities of DT performance that remain underexplored in the engineering community. Time-scale dependency refers to ensuring DTs function accurately across different time frames—ranging from rapid, short-term changes (e.g., vital sign fluctuations) to longer-term shifts (e.g., chronic disease progression)—an inherent characteristic of healthcare data. Model latency, is another key concern, as it may lead to delays in DT responses and compromise the relevance of DT-generated recommendations.

“… Substantial delays exist between data relationships, such as the time required to finalize revenue, billing, and coding charges, followed by additional lags before their integration into data warehouses like Vizient.”—Family medicine specialist #1.

Furthermore, the need for DTs to be personalized to individual provider or patient needs is often overlooked. Personalization is crucial because healthcare environments are highly variable, and “one-size-fits-all” solutions may fail to account for unique physiological, behavioral, or workload differences, thereby limiting the effectiveness and precision of DT interventions. A relevant participant quote regarding the DT personalization challenge is as follows:

“… The challenge with digital twins in healthcare is making them personalized enough to be useful without being too complex to implement. A one-size-fits-all approach won't work, but too much customization can slow things down and create integration issues.”—Engineer #2.

Financial and economic challenges, like unclear or intangible benefits and the lack of immediate returns, pose additional barriers to DT implementation. Our interviews repeatedly reflected concerns about justifying the investment in DT technology in the notoriously resource-constrained healthcare sector, which may require demonstrating clear, tangible outcomes. The difficulty in showcasing immediate benefits, coupled with uncertainty around ROI, often deters organizations from committing to DT projects. These issues reinforce the need for detailed, upfront cost-benefit analyses, especially when the demand for short-term results overshadows the importance of long-term goals.

Organizational challenges identified through CFIR 2.0 highlight the intricate nature of healthcare environments and the importance of insider perspectives. The pressure from top management for quick results can create obstacles to DT implementation, as the urgency for “quick wins” often leads to hasty adoption efforts that neglect long-term considerations essential for sustainable operations.

“… There's always pressure from leadership to show quick wins. They want results yesterday, but when you rush the process, you miss the foundation that makes the whole system sustainable in the long run.”—Organizational psychologist #1.

Additionally, the absence of established best practice guidelines complicates the navigation of DT complexities, further hindering effective and lasting implementation. Effective monitoring of KPIs, aligning DT projects with organizational goals, and fostering stakeholder engagement are all vital to success. One direct quote from an implementation scientist that captures the challenge of stakeholder engagement is as follows:

“… If you don't engage stakeholders early and often, you end up building a solution no one really wants or needs. The priorities keep shifting, and without that input, you're always playing catch-up.”—Implementation scientist #2.

Additionally, organizational culture plays a vital role, with factors like change fatigue, varying leadership styles, and the influence of “shadow stakeholders” complicating the adoption process. Moreover, healthcare organizations can request free trials from vendors before committing to DT technology, which adds complexity to implementation by potentially causing disruptions during the transition from trial systems to fully integrated solutions. These challenges highlight the importance of organizational readiness and leadership support necessary to sustain organizational change.

Operational challenges present substantial barriers, particularly regarding generalizability and resource availability. The adaptability of DTs to various healthcare contexts is a great technical perk but a major implementation concern as it raises questions about appropriate verification and validation strategies (131). Striking the balance between generalizability and over-fitting a specific operational context remains a key research challenge. Without this calibration flexibility, DTs risk delivering inconsistent results across different scenarios. Additionally, human decision-makers in the loop i.e., the healthcare managers and physicians, require transparent decision support systems that allow them to retain oversight and, if necessary, reverse DT-generated decisions. The scarcity of resources, both time and funding, further complicates the operationalization of DTs, making it difficult for organizations to fully capitalize on their potential. Moreover, scope management is another crucial operational challenge as identified from the participant's quote below:

“… Managing the scope of the digital twin is going to be really challenging. There's always this temptation to include everything about the healthcare system, but that's just not practical. Even if you start with a clear focus, it might not match what stakeholders actually need—or their priorities could shift over time.”—Family medicine specialist #2.

Personnel challenges identified through CFIR 2.0 range from staffing shortages to a lack of understanding of DT benefits. Due to the complexity of DT technology, adopters could struggle to see its direct impact on workflows or patient care. Additionally, already overburdened healthcare providers may view this new technology as an additional workload rather than a solution. The lack of time and motivation to engage with DTs can further impede adoption, especially when varying motivation levels among staff lead to uneven integration into daily practice. These issues underscore the need for comprehensive training and support systems to bridge the gap between technology and users. Moreover, the absence of prior research and evidence in real-world contexts could lead to skepticism, making it more difficult for stakeholders to trust DTs. Building this trust requires not only demonstrating DT efficacy but also ensuring transparency in their development and implementation—a fruitful area for further exploration, given its role in healthcare.

4.3 Knowledge transfer from DT research community to IS community

Our cross-comparative analysis shows that while CFIR 2.0 is effective in identifying many novel challenges in DT implementation within healthcare, it is not an exhaustive mechanism, particularly missing some well-identified issues recognized by the DT community. As outlined in Table 4, these primarily relate to technological or data-related challenges. It's important to note here that in several categories of challenges—financial, regulatory, operational, and personnel—CFIR 2.0 effectively captured the issues already well-documented by engineers.

Table 4
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Table 4. DT implementation challenges addressed in DT literature but not identified through CFIR 2.0-guided interviews.

This highlights an opportunity for knowledge transfer from the DT research community to the IS community and emphasizes the limitations of CFIR 2.0 in addressing challenges specific to emerging technologies like DTs. Below, we elaborate on these challenges and discuss why they are crucial for successful DT implementation.

Technological challenges are extensively discussed in the DT literature but were not revealed in our CFIR 2.0-guided interviews, even though specialist engineers were included as key stakeholders. This finding is noteworthy as healthcare organizations increasingly adopt technology within an already intricate and often inefficient socio-technical system. One of these challenges is effective DT modeling, which pertains to creating accurate digital representations of physical systems. Here, the complexity of modeling varies based on the system's nature and the desired fidelity, which in turn impacts DTs' efficacy (16). Sophisticated analytical approaches are needed to ensure sufficiently representative models of real-world processes (133); however, this was not revealed in our CFIR 2.0-guided interviews (93, 95, 113, 121). This finding highlights a limitation in CFIR 2.0, which lacks specific constructs to capture the nuances of DT modeling and its influence on desired implementation outcomes. As a result, healthcare stakeholders could often assume that modeling is well-executed, prioritizing generalizability and practical application while overlooking the complexities of the modeling process that are critical to achieving successful implementation. Another overlooked issue is DT twinning/connectivity, perhaps one of the most pressing challenges studied in the DT literature but not identified through CFIR 2.0. Connectivity between physical and virtual twins (P2V and V2P) is essential for compatibility and real-time data transfer. Any lag or disconnection can lead to misinformed decisions, hindering DT effectiveness (16, 23, 82).

Computational and data storage demands are challenges that are studied extensively in DT literature however were not explicitly recognized in our CFIR 2.0-guided interviews. DTs require substantial computational power and dynamic storage to process large datasets and run simulations (41, 107, 109, 111). This affects the feasibility and scalability of DTs, especially in resource-limited settings. Model accuracy and fidelity are also crucial, as they ensure reliability in predicting real-world scenarios (107, 112). Neglecting these could undermine trust and the eventual practical adoption of DTs.

In addition, sensor damage and failure represent significant hurdles, particularly since CFIR 2.0 does not address failure modes or the long-term sustainability of technological interventions. Sensors, key to DT data collection, are external interfaces that are vulnerable to environmental damage and degradation (134, 135). Their failure disrupts data collection, leading to erroneous outputs. For instance, sensor malfunction, caused by degradation, calibration issues, or environmental factors, can lead to missing or erroneous values. Separately, changes to EHR data formats can disrupt data extraction pipelines, creating incompatibilities that affect the continuity of the DT data flow (82). This underscores the need for robust sensor management and maintenance strategies, an area CFIR 2.0 does not capture.

Additionally, data-related challenges such as data collection and synchronization were not captured by CFIR 2.0. These involve sourcing data from various distributed, heterogeneous sources such as medical devices, EHR, and wearables (16, 23, 94, 112). Integrating these diverse data sources requires careful coordination of timing, frequency, and standardization. Accurate timestamps are crucial to establish clear temporal relationships between variables, while managing collection intervals and frequencies ensures smooth data synchronization.

Finally, some organizational challenges were also not identified by CFIR 2.0. For instance, developing appropriate business models is documented to be a vital component for assessing the economic and operational viability of DTs (95). Moreover, in industry, DT implementations typically use proprietary software tailored for DT development, whereas academic research relies on general-purpose simulation tools. This difference may contribute to a growing divide between industrial and academic DT implementations (132).

5 Discussion

5.1 Principal findings

DTs are advancing and transitioning into practice at an astonishing pace. For reference, the global DT market is projected to grow by 50% annually and reach ∼$195B by 2030 (136). Healthcare is expected to be a leading driver of this growth, rendering documentation of DT implementation challenges in HSs critical, particularly given the mixed success of past technology implementations in this sector (81, 128130). Nevertheless, there is a dichotomy between the DT community that is leading the maturation of this exciting technology and the IS community that is concerned with the transition of innovative approaches into practice. To that end, this study presented results from a case study on a conceptual provider workload DT to be implemented within a real-world clinical microsystem. Leveraging the CFIR 2.0 framework, we conducted interviews with key stakeholders to identify implementation challenges and compared them against those documented in the DT literature. This study reports two main findings: (i) CFIR 2.0's ability to identify DT implementation challenges and (ii) the opportunities for knowledge transfer between IS and DT research communities. We summarize these findings in five key points.

First, there was a notable overlap between issues documented in the DT communities and those we were able to identify through CFIR 2.0-guided interviews, albeit with differences in nuance and priority. This suggests that while CFIR 2.0 is not specifically designed for technology implementation, it is effective in identifying DT implementation challenges, especially when a comprehensive group of stakeholders is engaged methodically. This strength likely stems from the consolidated and generalized nature of the framework's constructs, building confidence in the broader applicability of the framework to various DT applications, and quite possibly similar emerging technologies.

Second, CFIR 2.0 sheds light on organizational and financial issues that are consistently overlooked by the DT community, and are essential for a successful implementation. These challenges were both numerous and diverse, suggesting that CFIR 2.0 could be useful given the versatility of DTs, while concurrently calling for a more explicit consideration of these issues within the DT community. However, it is important to note that while CFIR 2.0 helps identify these challenges, it does not offer solutions, hinting at an opportunity for collaboration between the DT and IS communities to address these obstacles.

Third, and perhaps more relevant for the IS community, we found that CFIR 2.0 does not adequately address several critical technological and data-related challenges that are well-documented in the DT community. This limitation posits that CFIR 2.0 could benefit from certain modifications to capture these issues, particularly in the Innovation and Implementation Process domains. While this paper does not aim to propose a CFIR 3.0, our findings indicate that CFIR 2.0 should be used with caution, recognizing its limitations—particularly when applied to guide the implementation of advanced technologies.

Fourth, our findings highlight the value of using structured yet adaptable frameworks for implementing complex and flexible technologies like DTs. To recall, although we only picked a representative case study, DTs could be developed to represent any system of interest within the broader healthcare environment (16). Given this range of possibilities, general implementation frameworks could help anticipate and mitigate potential challenges, as illustrated in this work. Regarding the generalizability of these challenges, although this study is based on a specific case study, identified challenges are likely to apply to other DT use cases, and quite possibly to other high-tech implementation contexts that may lie at the intersection of AI, IoT, smart sensors, and decision-support (137, 138). Nevertheless, while we have a reasonable level of confidence in the relevance of these findings, their broader generalizability is contingent on further research.

Lastly, this study does not exhaustively document all DT implementation challenges due to our research design choices and the emerging nature of the DT literature. Our study relied on semi-structured interviews with a purposively selected group of stakeholders, which, while insightful, may not have captured the full spectrum of perspectives. It is plausible that many implementation issues remain unrecognized by both the DT community and our CFIR 2.0-guided analysis. Additionally, the findings are based on a single case study conducted within a family medicine clinic, which may limit their generalizability to other healthcare settings, particularly those with different organizational structures or resource constraints. Therefore, our findings should only be interpreted as a conservative estimate of the challenges involved in implementing DTs in HSs.

5.2 Points of departure from the literature

This study presents a significant point of departure from prior work by providing the first empirical assessment of CFIR 2.0's applicability in capturing DT implementation challenges within HSs, along with a comparison of these findings to the state of knowledge in the DT literature. As summarized in Table 5, previous research primarily relied on literature reviews (16, 82) and conceptual analyses (20) to examine DT adoption, while CFIR applications in healthcare employed qualitative methods in different interventions (139), with no focus on DT-specific implementations. In contrast, our study systematically applies CFIR 2.0 to a real-world DT implementation case in a family medicine clinic, validating its strengths and limitations using empirical data.

Table 5
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Table 5. A summary of points of departure from previous work (with representative references).

A key distinction lies in our methodological approach. Prior DT research is predominantly conceptual in nature, with minimal emphasis on the implementation side (16). Additionally, CFIR-based healthcare research lacked a DT-specific evaluation. Our study integrates semi-structured interviews with stakeholders and a comparative analysis with existing literature to assess CFIR 2.0's empirical validity. This enables a rich evaluation of its effectiveness in identifying organizational and financial barriers while revealing its shortcomings in capturing technological and data-related challenges that are fundamental to successful DT implementation in HSs.

Furthermore, Table 5 highlights how our study bridges the gap between engineering and implementation science perspectives. To elaborate, prior DT research that originates from the engineering community often overlooked behavioral and organizational factors (21). On the other hand, CFIR-based healthcare implementation studies had a very limited overview of engineering challenges, particularly those related to technologies such as DTs (144) that are considerably more complex (5) than let's say a simple diagnostic tool or a stand-alone algorithm to support some decision-making function (77, 146149). Our findings challenge the implicit assumption that organizational factors dominate digital health adoption (150). Instead, we demonstrate that technological and data-centric challenges are equally critical, yet CFIR 2.0 fails to comprehensively capture them. This leads to our next point.

Lastly, this study provides a proof by contradiction, against the implicit assumption that CFIR is an effective framework to identify implementation challenges associated with high-tech, data-intensive new technologies (76, 151, 152). By documenting its limitations in guiding DT adoption, we highlight the need for an expanded CFIR model that integrates technological and data-specific constructs. This need aligns with the broader challenges identified in the recent NASEM report, which underscores foundational research gaps in DT development, including computational, statistical, and translational challenges that hinder their full realization (15). We anticipate that addressing these limitations will only become more pressing over time. As summarized in Table 5, this work provides a foundation for refining implementation science frameworks and DT adoption strategies, offering valuable insights for both digital health research and real-world DT deployment in HSs.

5.3 Theoretical implications

This study advances implementation science by critically examining how and to what extent CFIR 2.0 can identify DT implementation challenges within HSs. While CFIR 2.0 effectively captures organizational, financial, and sociotechnical barriers, it falls short in addressing critical technological and data-related issues. This limitation has significant theoretical implications, as it challenges the assumption that CFIR 2.0 is universally applicable to high-tech healthcare implementations. By documenting the nuanced set of factors that CFIR 2.0 omits, our study serves as a proof by contradiction to its claimed comprehensiveness, reinforcing the need for a more adaptable framework that integrates constructs tailored to digital health technologies.

By systematically contrasting empirical results with existing DT literature, this study demonstrates that technological and data-centric factors are not secondary concerns but fundamental to successful DT adoption. This finding challenges the prevailing assumption in the DT community that implementation challenges are predominantly organizational. By addressing this gap, our study bridges the disciplinary divide between implementation science and DT engineering, laying the groundwork for future interdisciplinary research on digital health technologies.

Methodologically, this study makes key contributions by applying CFIR 2.0 to a real-world case study, rather than relying on theoretical analysis alone, ensuring that the framework's applicability is assessed in an operational healthcare setting. Furthermore, our structured interviews with diverse stakeholders provide a richer and more nuanced dataset, capturing insights that would be missed in literature-based analyses.

Additionally, by identifying specific technological and data challenges that CFIR 2.0 fails to address, this study not only refines implementation science frameworks but also enhances DT literature by highlighting overlooked barriers. The rigorous comparison of CFIR 2.0's coverage against DT engineering literature ensures that findings are empirically grounded rather than assumed, setting a methodological precedent for future research.

5.4 Managerial implications

The findings of this study provide actionable insights for healthcare administrators, policymakers, and DT developers seeking to optimize implementation strategies; by outlining the nature of multi-faceted factors that (i) can be identified by the CFIR 2.0-guided interviews, (ii) will be missed if CFIR 2.0 is adopted as a guidance mechanism, and (iii) are identified both through CFIR 2.0 and in DT literature. Healthcare leaders can leverage our results to design evidence-based adoption frameworks that address both technical and social barriers, ensuring that DT initiatives align with broader institutional goals. Specifically, this study documents that fostering a culture of innovation readiness, integrating structured change management programs, and prioritizing stakeholder engagement is essential for successful implementation.

Additionally, DT developers and engineers must collaborate closely with IS experts to navigate non-technical barriers, such as workflow integration, training infrastructure, and user trust. Importantly, our findings also uncover key knowledge gaps and highlight opportunities for knowledge transfer, underscoring the potential for enhanced collaboration between the implementation science and DT communities. Such collaboration can drive the development of integrated frameworks and joint initiatives that address both technical and non-technical challenges.

Our study also highlights the importance of iterative evaluation mechanisms for the successful sustainment of DT technologies, ensuring that DTs are continuously adapted to the evolving needs of healthcare environments. These insights could serve as a strategic roadmap for managers to plan for, and execute, successful DT implementation in healthcare. We contend that the successful transition of this exciting technology into practice will remain a pressing challenge in years to come.

5.5 Future research directions

Future research could focus on refining the CFIR 2.0 framework to better capture the technological and data-related complexities inherent in DT implementation within HSs. Specifically, integrating constructs related to DT modeling and twinning, real-time data synchronization, sensor reliability, and data quality would enhance the framework's ability to address data-driven healthcare interventions. Longitudinal studies across diverse healthcare environments can be explored to validate the generalizability of these findings and to explore how organizational, technological, and sociotechnical dynamics evolve during DT adoption. Additionally, fostering interdisciplinary collaborations between the engineering and healthcare communities is essential for effectively bridging knowledge gaps. Such collaborative efforts can inform best practices for overcoming both technical and organizational barriers, thereby accelerating the transition of emerging technologies like DTs into practical healthcare solutions.

6 Conclusions

Within the field of implementation science, there have been calls to “specify and test mechanistic pathways… about drivers, moderators and mediators of implementation outcomes” and provide “finer-grained identification” of variables that influence and precede implementation outcomes (33). We sought to go beyond the use of CFIR 2.0 to better understand the organization and functioning of clinical microsystems and use it as a pre-implementation planning and evaluation tool for healthcare leaders and managers. Our study demonstrates the effectiveness of the CFIR 2.0 framework in identifying a significant portion of the challenges associated with DT implementation within HSs, while also highlighting its limitations in addressing technological and data-related issues.

As emphasized throughout this paper, the context is crucial for the development of accurate DTs, their seamless transition into practice, and sustained use by healthcare professionals. The framework's capacity to capture critical organizational and financial challenges that are commonly disregarded in the DT literature illustrates its value and points to an opportunity for informing the DT research community. By systematically bridging the knowledge gap between implementation science and DT communities, this study provides a foundation for interdisciplinary collaboration. The findings highlight how leveraging CFIR 2.0 can aid in identifying implementation barriers that extend beyond technical concerns, thereby facilitating a more holistic approach to DT adoption in healthcare. That being said, while CFIR is intended to be a universally applicable tool for any intervention in healthcare, the framework is deficient in capturing technological and data-related issues for emerging, complex, and data-intensive technologies such as DTs. This limitation underscores the necessity of refining existing implementation frameworks or developing hybrid models that integrate both sociotechnical and engineering considerations to ensure a more effective transition of DTs into clinical settings.

Beyond theoretical implications, these findings have practical significance for healthcare administrators and policymakers seeking to implement DTs in real-world settings. Understanding the multifaceted challenges identified in this study can inform the design of more effective strategies that align technological capabilities with organizational readiness, regulatory requirements, and stakeholder engagement. By fostering collaboration between the IS and DT communities, future research can explore structured pathways for optimizing DT implementation, thereby accelerating their impact on healthcare efficiency, provider well-being, and patient outcomes. Finally, this study reported insights for future DT implementations along with a foundation for enhancing CFIR 2.0's applicability to cutting-edge technologies across various healthcare contexts.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Ethics statement

The studies involving humans were approved by Virginia Tech Institutional Review Board. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.

Author contributions

MX: Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft. TT: Supervision, Writing – review & editing. SP: Writing – review & editing. VZ: Writing – review & editing. JE: Writing – review & editing.

Funding

The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by Virginia Tech's Institute for Society, Culture, and Environment (ISCE) and the Destination Areas 2.0 Planning and Development Grant.

Acknowledgments

The authors would like to express their sincere gratitude for the support provided by Virginia Tech's Institute for Society, Culture, and Environment (ISCE) and the Destination Areas 2.0 Planning and Development Grant. The gratitude extends to the interviewees, whose valuable time and insights have enabled this research.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declare that no Generative AI was used in the creation of this manuscript.

Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.

Publisher's note

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Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fdgth.2025.1611225/full#supplementary-material

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Keywords: digital twin, technology implementation, implementation science, CFIR, healthcare systems engineering

Citation: Xames MD, Topcu TG, Parker SH, Zagarese V and Epling JW (2025) Evaluating CFIR 2.0 in identifying digital twin implementation challenges in healthcare: bridging the dichotomy between engineering and healthcare communities. Front. Digit. Health 7:1611225. doi: 10.3389/fdgth.2025.1611225

Received: 22 April 2025; Accepted: 28 August 2025;
Published: 15 September 2025.

Edited by:

Antonella Carbonaro, University of Bologna, Italy

Reviewed by:

Serena Moscato, University of Bologna, Italy
Sai Phanindra Venkatapurapu, AstraZeneca Pharmaceuticals LP, United States

Copyright: © 2025 Xames, Topcu, Parker, Zagarese and Epling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Md Doulotuzzaman Xames, eGFtZXNAdnQuZWR1

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.