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Peripheral Regulators of Obesity

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Front. Endocrinol. | doi: 10.3389/fendo.2018.00420

Involvement of TRPV1 channels in energy homeostasis

 Stewart Christie1, Gary A. Wittert1, 2,  Hui Li1, 2 and  Amanda J. Page1, 2*
  • 1Adelaide Medical School, University of Adelaide, Australia
  • 2Nutrition and Metabolism, South Australian Health and Medical Research Institute, Australia

The ion channel TRPV1 is involved in a wide range of processes including nociception, thermosensation and, more recently discovered, energy homeostasis. Tightly controlling energy homeostasis is important to maintain a healthy body weight, or to aid in weight loss by expending more energy than energy intake. TRPV1 may be involved in energy homeostasis both in the control of food intake and energy expenditure and therefore maybe a potential therapeutic target for the treatment of obesity.

Keywords: TRPV1, endocannabinoid system, endovanilloids, Obesity, Metabolism, Appetite Regulation

Received: 30 Mar 2018; Accepted: 04 Jul 2018.

Edited by:

Andrew J. McAinch, Victoria University, Australia, Australia

Reviewed by:

Thomas A. Lutz, Universität Zürich, Switzerland
Denis P. Blondin, Université de Sherbrooke, Canada  

Copyright: © 2018 Christie, Wittert, Li and Page. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Amanda J. Page, University of Adelaide, Adelaide Medical School, Adelaide, 5000, South Australia, Australia,