The evolving importance of insulin signalling in podocyte health and disease
- 1University of Bristol, United Kingdom
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide, occuring in approximately one-third of diabetic patients. One of the earliest hallmarks of DKD is albuminuria, often occurring following disruptions to the glomerular filtration barrier. Podocytes are highly specialised cells with a central role in filtration barrier maintenance; hence, podocyte dysfunction is a major cause of albuminuria in many settings, including DKD. Numerous studies over the last decade have highlighted the importance of intact podocyte insulin responses in the maintenance of podocyte function. This review summarises our current perspectives on podocyte insulin signalling, highlighting evidence to support the notion that dysregulated podocyte insulin responses contribute towards podocyte damage, particularly during the pathogenesis of DKD.
Keywords: podocyte, insulin signalling, diabetic kidney disease (DKD), Insulin resisitance, diabetes, Albuminuria, Podocyte metabolism
Received: 31 Aug 2018;
Accepted: 05 Nov 2018.
Edited by:Sanna H. Lehtonen, University of Helsinki, Finland
Reviewed by:Pedro Geraldes, Université de Sherbrooke, Canada
Christopher E. Pedigo, Yale School of Medicine, Yale University, United States
Copyright: © 2018 Lay and Coward. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Abigail C. Lay, University of Bristol, Bristol, United Kingdom, email@example.com