Impact Factor 3.519

Frontiers journals are at the top of citation and impact metrics

Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2018.00700

Subclinical hypothyroidism in polycystic ovary syndrome: a systematic review and meta-analysis

Xiaohong Ding1, Lili Yang2, Rong Tang3, Qianqian Chen1, Jiexue Pan1, Haiyan Yang1, Zimiao Chen1, Xia Chen1 and  Liangshan Mu1*
  • 1First Affiliated Hospital of Wenzhou Medical University, China
  • 2Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, China
  • 3Wenzhou Medical University, China

Background: The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been reported in several studies,but it is not well recognized. The aim of this study was to evaluate the prevalence of SCH in women with PCOS.
Methods: An extensive literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases. All articles published before May 2018 was considered for eligibility. No language restrictions were implemented. The prevalence of SCH in PCOS was performed by the meta-analysis to produce an odds ratio (OR) with 95% confidence interval (CI).
Results: A total of 6 studies including 692 PCOS patients and 540 controls were eligible for the meta-analysis. The combined odds ratio (OR) of SCH risk for women with PCOS compared with controls was 2.87 (95% CI=1.82-9.92; P <0.000001). The OR increased to 3.59 when limiting TSH cut-off.
Conclusions: This meta-analysis demonstrated that women with PCOS were more likely to develop SCH.

Keywords: subclinical hypothyroidism, thyroid, Polycystic Ovary Syndrome, Prevalence, Meta-analysis

Received: 25 Aug 2018; Accepted: 06 Nov 2018.

Edited by:

Alessandro Antonelli, University of Pisa, Italy

Reviewed by:

Mario Rotondi, University of Pavia, Italy
Roberto Vita, Università degli Studi di Messina, Italy  

Copyright: © 2018 Ding, Yang, Tang, Chen, Pan, Yang, Chen, Chen and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Liangshan Mu, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China,