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Follicle-Stimulating Hormone: Beyond Fertility

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Front. Endocrinol. | doi: 10.3389/fendo.2018.00707

Structure-function Relationships of the Follicle-Stimulating Hormone Receptor

  • 1Red de Apoyo a la Investigación, National Autonomous University of Mexico, Mexico
  • 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico
  • 3Universidad Autónoma Metropolitana Unidad Lerma, Mexico
  • 4University at Albany, United States

The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This structurally complex receptor belongs to the G-protein coupled receptor (GPCR) superfamily of membrane receptors. As with the other structurally similar glycoprotein hormone receptors (the thyroid-stimulating hormone and luteinizing hormone-chorionic gonadotropin hormone receptors), the FSHR is characterized by a large extracellular domain, where binding to FSH occurs, linked to the signal specificity subdomain or hinge region. This region is involved in ligand-stimulated receptor activation whereas the seven transmembrane domain is associated with receptor activation and transmision of the activation process to the intracellular loops comprised of amino acid sequences, which predicate coupling to effectors, interaction with adapter proteins, and triggering of downstream intracellular signaling. In this review, we describe the most important structural features of the FSHR intimately involved in regulation of FSHR function, including trafficking, dimerization and oligomerization, ligand binding, agonist-stimulated activation and signal transduction.

Keywords: follicle-stimulating hormone receptor (FSHR), Follitropin receptor, Structure, G protein-coupled receptor (GPCR), Glycoprotein hormone receptors

Received: 19 Sep 2018; Accepted: 09 Nov 2018.

Edited by:

Ilpo Huhtaniemi, Imperial College London, United Kingdom

Reviewed by:

Peter Stanton, Hudson Institute of Medical Research, Australia
Livio Casarini, Università degli Studi di Modena e Reggio Emilia, Italy
Kim Jonas, St George's, University of London, United Kingdom  

Copyright: © 2018 Ulloa-Aguirre, Zariñán, Jardón-Valadez and Dias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Alfredo Ulloa-Aguirre, National Autonomous University of Mexico, Red de Apoyo a la Investigación, Ciudad de Mexico, 10101, D.F., Mexico, aulloaa@servidor.unam.mx