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Front. Endocrinol. | doi: 10.3389/fendo.2018.00751

Influence of the IGFBP3 -202A/C Gene Polymorphism on Clinical Features and Surgery Outcome in Acromegalic Patients

 Ming Gao1,  Bin Zhu1, Ping Li2, Guojun Zhang1, Kelin Chen1, Hong Lv1, Ruimin Ma1, Linmin Zhang1,  Yubo Fan3 and  Xixiong Kang1*
  • 1Beijing Tiantan Hospital, Capital Medical University, China
  • 2Department of Endocrinology, Yuncheng Central Hospital, Shanxi Medical University, China
  • 3Beihang University, China

Purpose: Excess growth hormone secretion in acromegaly patients results in increased levels of IGF-1 expression, which causes the clinical manifestations of acromegaly. IGF-1 levels are attenuated by IGFBP3, and a polymorphism in the promoter of IGFBP3 is known to affect the circulating level of IGFBP3 protein. The aim of the study was to evaluate the association of the IGFBP3 gene polymorphism with clinical features and surgery outcomes in acromegaly. We also investigate the difference in IGFBP3 polymorphism between acromegaly and general population.

Methods: The study included 102 acromegalic patients and 142 sex- and age-matched healthy controls. The genotyping of IGFBP3 was carried out using the MassARRAY method. Patients were followed up for 4-12 months to estimate the neurosurgical effects. Clinical data were obtained from the medical records.

Results: The CC genotype, which is associated with decreased IGFBP3 levels, was less common in acromegaly patients than among the healthy controls; although, this correlation was not significant (P=0.056). There was no association of the IGFBP3 gene polymorphism with glucose, lipid, phosphorus, blood urea nitrogen, creatinine or uric acid levels. Additionally, there was no association between tumor size, texture, or hemorrhage/cyst, except that more patients with the C allele (P=0.054) needed additional treatment post-operation than did patients carrying the A allele (OR 1.985, 95% CI 0.983-4.008). Moreover, higher IGF-1 values after treatment were observed in patients carrying the C allele (P=0.012 and P=0.014 according to the additive model and dominant model, respectively).

Conclusion: Polymorphisms in IGFBP3 may not influence metabolic parameters or pituitary tumor characteristics in acromegalic patients, but they may be associated with the hormone levels and surgery effects.

Keywords: Acromegaly, IGFBP3 -202A/C polymorphism, rs2854744, Clinical feature, surgery outcome

Received: 14 Sep 2018; Accepted: 27 Nov 2018.

Edited by:

Antonio Brunetti, Università degli studi Magna Græcia di Catanzaro, Italy

Reviewed by:

Shannon W. Davis, University of South Carolina, United States
Amit Tirosh, Sheba Medical Center, Israel  

Copyright: © 2018 Gao, Zhu, Li, Zhang, Chen, Lv, Ma, Zhang, Fan and Kang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xixiong Kang, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China,