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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00473

Epigenetics and Female Reproductive Aging

Isaac Charmani1 and  David L. Keefe2*
  • 1School of Medicine, New York University, United States
  • 2Langone Medical Center,New York University, United States

As a result of many social and economic factors, increasing numbers of women are delaying childbirth until a more advanced age [1]. Increasing maternal age has resulted in well documented decreases in fertility [2; 3], and increases in aneuploidy [4], and pregnancy complications [5; 6; 7]. While these risks are clear, the underlying physiological processes that result in these outcomes are much less well defined. Proposed mechanisms involve neuroendocrine deficiency [8; 9], telomere length, meiosis abnormalities [10; 11], mitochondrial dysfunction [12; 13], as well as epigenetic modifications. In this review, we focus on the age- related epigenetic changes that have been found in female reproductive organs, and the effect these changes may contribute to female reproduction.

Keywords: DNA, Infertility, Aging, reproductive, epigenetics

Received: 25 Jul 2018; Accepted: 28 Jun 2019.

Edited by:

Lori R. Bernstein, Pregmama, LLC, United States

Reviewed by:

Hao Chen, School of Medicine, Nantong University, China
T. Rajendra Kumar, University of Colorado Anschutz Medical Campus, United States  

Copyright: © 2019 Charmani and Keefe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. David L. Keefe, Langone Medical Center,New York University, New York City, United States, david.keefe@nyumc.org