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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00494

Modulatory effects of plant polyphenols on bone remodeling: a prospective view from the bench to bedside.

 Vanessa Nicolin1*,  Nunziatina De Tommasi2,  Stefania L. Nori2, Fulvia Costantinides3,  Federico Berton3 and Roberto Di Lenarda3
  • 1Department of Medical, Clinical and Health Sciences, University of Trieste, Italy
  • 2Department of Pharmacy, University of Salerno, Italy
  • 3Clinical University Department of Medical and Surgical Medical Sciences, University of Trieste, Italy

During the past, a more comprehensive knowledge of mechanisms implicated in bone resorption processes has driven researchers to develop a compound library of many small molecules that specifically interfere with the genesis of osteoclast precursors cells. Natural compounds that suppress osteoclast commitment may have therapeutic value in treating pathologies associated with bone resorption like osteoporosis, rheumatoid arthritis, bone metastasis and periodontal disease. The present review is focused on the current knowledge on the polyphenols derived from plants that could be efficacious in suppressing osteoclast differentiation and bone resorption.

Keywords: biomolecules, polyflavonoids, Bone Remodeling, titanium implant, coating surfaces

Received: 05 Mar 2019; Accepted: 08 Jul 2019.

Edited by:

Giacomina Brunetti, University of Bari Aldo Moro, Italy

Reviewed by:

Gabriele D'Amato, U.O.C di terapia intensiva neonatale, Ospedale Di Venere, Italy
Mario Rende, University of Perugia, Italy  

Copyright: © 2019 Nicolin, De Tommasi, Nori, Costantinides, Berton and Di Lenarda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Vanessa Nicolin, University of Trieste, Department of Medical, Clinical and Health Sciences, Trieste, 34149, Italy,