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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00786

Association of anthropometric indices with metabolic phenotypes of obesity in children and adolescents: the CASPIAN-V study

 Moloud Payab1,  Mostafa Qorbani2*, Nazila Shahbal1, Mohammad Esmaeil Motlagh1, Shirin Hasani Ranjbar1, Hoda Zahedi1, Gita Shafeii1, Hasan Ziaodini1, Mohammad ali pourmirzaeei3,  Ramin Heshmat1 and  Roya Kelishadi3
  • 1Tehran University of Medical Sciences, Iran
  • 2University of Tehran, Iran
  • 3Isfahan University of Medical Sciences, Iran

Background
Obesity, particularly in the upper part of body, is a major health problem. Neck circumference (NC) and wrist circumference (WrC) is a relatively new method of differentiating between normal and abnormal fat distributions. This study aimed to evaluate the association of NC, hip circumference (HC), and WrC with different phenotypes of obesity and their metabolic status.
Methods
In this multi-centric cross-sectional study, 4200 students aged 7–18 years were selected using multistage cluster random sampling method from 30 provinces of Iran in 2014. Metabolic syndrome (MetS) was defined based on the ATP III criteria modified for the pediatric age group. The subjects were classified into four groups according to their weight and metabolic status: metabolically healthy obese (MHO), metabolically non-healthy non-obese (MNHNO), metabolically non-healthy obese (MNHO), and metabolically healthy non-obese (MHNO).
Results
A significant but different association was documented between NC, HC, and WrC and obesity phenotypes in the entire population. Also, a significant but different association was found between NC, HC, and WrC and metabolic phenotypes in the entire population. In the multinomial logistic regression, the association of the different obesity phenotypes with the study anthropometric indices increased significantly by increasing NC, WrC, and HC. Also per one unit increment in NC, HC, and Wrc the odds of MHO, MNHNO, MNHO increased compared to the MHNO phenotype.
Conclusion
In children and adolescents, HC, NC and WrC are significantly associated with obesity phenotypes and their metabolic status, and are suggested to be innovativ, low-cost, and alternative tools for assessing them in different age and sex pediatric age groups.

Keywords: Obesity, Obesity phenotypes, abdominal obesity, Anthropometric indices, Metabolic syndome

Received: 25 Jun 2019; Accepted: 29 Oct 2019.

Copyright: © 2019 Payab, Qorbani, Shahbal, Motlagh, Hasani Ranjbar, Zahedi, Shafeii, Ziaodini, pourmirzaeei, Heshmat and Kelishadi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Mostafa Qorbani, University of Tehran, Tehran, Iran, mqorbani1379@yahoo.com