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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00831

Prognostic roles of central carbon metabolism-associated genes in patients with low-grade glioma

 Meng Guo1, Li Wang1, Kai Wang1* and  Lei Zhang1*
  • 1Xijing Hospital, Fourth Military Medical University, China

Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism-associated genes contribute to the outcomes of glioma and astrocytoma is not well understood.
Method: We studied the profiles of 63 genes involved in central carbon metabolism in 514 relatively low-grade glioma patients. The different distributions of gene expression in gliomas and astrocytoma were identified. The differential gene expression between each cohort and the correlations with prognosis were detected. Finally, we built a tentative model to detect the prognostic roles of carbon metabolism-associated genes in astrocytoma.
Result: Two primary clusters and four sub-clusters with significantly different overall survival were identified in glioma. The differences of histological diagnoses, grade, tumor site and age were detected between each cluster. Comparing with other histological types, patients with astrocytoma exhibited the worst prognosis. Between astrocytoma patients with poor and favourable prognosis, expression profiles of 11 genes were significantly discrepant. We detected that 18 genes were respectively correlated with overall survival in astrocytoma, moreover, four genes (RAF1, AKT3, IDH1, and FGFR1) were detected as dependent variables for the prediction of the survival status of astrocytoma patients and were capable to predict the survival.
Conclusion: Central carbon metabolism-associated genes are differentially expressed in all patients with glioma and histological subtype astrocytoma. The gene expression profile is significantly associated with clinical manifestations. These results suggested that both the multigene expression patterns and individual central carbon metabolism-associated genes were potentially capable to predict the prognosis of patients with low-grade glioma.

Keywords: low-grade glioma, Astrocytoma, prognosis, Metabolism, Gene Expression

Received: 08 May 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Guo, Wang, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Kai Wang, Xijing Hospital, Fourth Military Medical University, Xi’an, China, wkslashking@163.com
Prof. Lei Zhang, Xijing Hospital, Fourth Military Medical University, Xi’an, China, zhangleiafmmu@163.com