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Front. Immunol. | doi: 10.3389/fimmu.2018.00300

Human Langerhans cells with pro-inflammatory features relocate within psoriasis lesions.

  • 1Department of Medicine Solna, Karolinska Institute (KI), Sweden
  • 2Dermatology and Venereology, Karolinska University Hospital, Sweden

Psoriasis is a common skin disease that presents with well-demarcated patches of inflammation. Recurrent disease in fixed areas of the skin indicates a localised disease memory that is preserved in resolved lesions. In line with such concept, the involvement of tissue resident immune cells in psoriasis pathology is increasingly appreciated. Langerhans cells (LCs) are perfectly placed to steer resident T cells as well as local tissue responses in psoriasis. Here we present an overview of the current knowledge of LCs in human psoriasis, including findings that highlight proinflammatory features of LCs in psoriasis lesions. We also review the literature on conflicting data regarding LC localisation and functionality in psoriasis. Our review highlights that further studies are needed to elucidate the molecular mechanisms that drive LCs functionality in inflammatory diseases.

Keywords: Langerhans Cells, human, Psoriasis, microenvironment, Inflammation, Lc function, LC localisation

Received: 16 Nov 2017; Accepted: 02 Feb 2018.

Edited by:

Clare L. Bennett, University College London, United Kingdom

Reviewed by:

Kiwook Kim, School of Medicine, Washington University in St. Louis, United States
Botond Z. Igyártó, Baylor Scott & White Research Institute, United States  

Copyright: © 2018 Eidsmo and Martini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Liv Eidsmo, Karolinska Institute (KI), Department of Medicine Solna, Center for Molecular Medicine (CMM) L8:02, Karolinska Universitetssjukhuset Solna, Solna, 171 77, Sweden, liv.eidsmo@ki.se