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Front. Immunol. | doi: 10.3389/fimmu.2018.00804

Flexible signaling of myeloid C-type lectin receptors in immunity and inflammation

 Carlos del Fresno1*,  Salvador Iborra1, Paula Saz-Leal1, María Martínez-López1 and  David Sancho1*
  • 1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain

Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which leads to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation.

Keywords: Lectin receptors, signaling, Monocytes, Macrophages, Dendritic Cells, Immunity, Innate, Inflammation

Received: 19 Dec 2017; Accepted: 03 Apr 2018.

Edited by:

Roland Lang, Universitätsklinikum Erlangen, Germany

Reviewed by:

Yvette Van Kooyk, Medical Center, VU University Amsterdam, Netherlands
Marit Inngjerdingen, Oslo University Hospital, Norway
Michael R. Daws, University of Oslo, Norway  

Copyright: © 2018 del Fresno, Iborra, Saz-Leal, Martínez-López and Sancho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Carlos del Fresno, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain,
Dr. David Sancho, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain,