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Long Non-Coding RNAs and Immunity

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Front. Immunol. | doi: 10.3389/fimmu.2018.02977

Circular RNAs and their Emerging Roles in Immune Regulation

  • 1Fudan University, China
  • 2Children's Hospital, Fudan University, China

Circular ribonucleic acid (RNA) molecules (circRNAs) are covalently closed loop RNA molecules with no 5′ end caps or 3' poly (A) tails, which are generated by back-splicing. Originally, circRNAs were considered to be byproducts of aberrant splicing. However, in recent years, development of high-throughput sequencing has led to gradual recognition of functional circRNAs, and increasing numbers of studies have elucidated their roles in cancer, neurologic diseases, and cardiovascular disorders. Nevertheless, studies of the functions of circRNAs in the immune system are relatively scarce. In this review, we detail relevant research on the biogenesis and classification of circRNAs, describe their functional mechanisms and approaches to their investigation, and summarize recent studies of circRNA function in the immune system.

Keywords: circRNA, biogenesis, Research approaches, Immune Regulation, Cellular function, biomarkers

Received: 18 Sep 2018; Accepted: 04 Dec 2018.

Edited by:

Adam Williams, Jackson Laboratory, United States

Reviewed by:

Yi Zhao, West China Hospital, Sichuan University, China
Grace Chen, Yale University, United States  

Copyright: © 2018 Zhou, Fu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yufeng Zhou, Fudan University, Shanghai, China, yfzhou1@fudan.edu.cn