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Front. Immunol. | doi: 10.3389/fimmu.2019.01952

A Comparison of Phenotypic and Functional properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells.

 Reenam S. Khan1 and Philip N. Newsome1*
  • 1University of Birmingham, United Kingdom

Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to helpin determining which would be the superior cell type for different applications.

Keywords: Mesenchymal stromal cell, Multipotent adult progenitor cell, Cellular therapeutics, Cell Biology, Immunomodulation

Received: 29 Mar 2019; Accepted: 02 Aug 2019.

Edited by:

Guido Moll, Charité Medical University of Berlin, Germany

Reviewed by:

Pablo Menendez, Andusian Health Service, Spain
Charles S. Cox, McGovern Medical School, University of Texas, United States
Bernard P. Mahon, Maynooth University, Ireland  

Copyright: © 2019 Khan and Newsome. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Philip N. Newsome, University of Birmingham, Birmingham, United Kingdom, p.n.newsome@bham.ac.uk