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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Parasite Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1389551

The impact of cholesteryl ester transfer protein on the progression of cutaneous leishmaniasis

Provisionally accepted
FRANCISCA ELDA BATISTA DANTAS FRANCISCA ELDA BATISTA DANTAS 1Christiane Ozaki Christiane Ozaki 1Cinthia S. Portugal Cinthia S. Portugal 1Bernardina A. Uscata Bernardina A. Uscata 1KELLY SANTANA KELLY SANTANA 1Edite H. Kanashiro Edite H. Kanashiro 1Valeria S. Nunes Valeria S. Nunes 1Amaro N. Duarte-Neto Amaro N. Duarte-Neto 1wagner L. Tafuri wagner L. Tafuri 2Mirian N. Sotto Mirian N. Sotto 1Luiza Reis Luiza Reis 1Hiro Goto Hiro Goto 1PATRICIA M. CAZITA PATRICIA M. CAZITA 1*
  • 1 University of São Paulo, São Paulo, Rio Grande do Sul, Brazil
  • 2 Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

The final, formatted version of the article will be published soon.

    Pathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation of lipoproteins. The cholesteryl ester transfer protein (CETP) has a role in lipoprotein metabolism and inflammation. We searched the lesion development in Leishmania (L.) amazonensis-infected human CETP transgenic-C57BL6/J mice (CETP). At 12 weeks of infection, CETP mice exhibited reduced lesion size, parasitism, and improved healing compared with infected control wild-type (WT) mice. We observed decreased CD68 + and increased CD163 + and CD206 + cells (M2 macrophage profile). The infected CETP mice displayed lower cholesterol levels in HDL and increased triglycerides in VLDL. Reduced CD36 receptor expression in the infected CETP mice correlated with healing and parasite reduction. In the in vitro experiment, the infected CETP macrophages showed lower parasite load, decreased arginase activity, and increased NO production compared with infected WT macrophages.Participation of CETP in Leishmania (L.) amazonensis infection development suggests its role in the modulation of immune response.

    Keywords: Cholesteryl ester transfer protein, cutaneous leishmaniasis, Leishmania L. amazonensis, Mice, Infection, lipoprotein, macrophage, Arginase

    Received: 21 Feb 2024; Accepted: 08 May 2024.

    Copyright: © 2024 BATISTA DANTAS, Ozaki, Portugal, Uscata, SANTANA, Kanashiro, Nunes, Duarte-Neto, Tafuri, Sotto, Reis, Goto and CAZITA. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: PATRICIA M. CAZITA, University of São Paulo, São Paulo, Rio Grande do Sul, Brazil

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