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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1406538
This article is part of the Research Topic Community Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume II View all 7 articles
Role of Long non-coding RNA in Inflammatory Bowel Disease
Provisionally accepted- 1 Jinhua Central Hospital, Jinhua, Zhejiang Province, China
- 2 Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China
Inflammatory bowel disease (IBD) is a group of recurrent chronic inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC). Although IBD has been extensively studied for decades, its cause and pathogenesis remain unclear.Existing research suggests that IBD may be the result of an interaction between genetic factors, environmental factors and the gut microbiome. IBD is closely related to non-coding RNAs (ncRNAs). NcRNAs are composed of microRNA(miRNA), long non-coding RNA(lnc RNA) and circular RNA(circ RNA). Compared with miRNA, the role of lnc RNA in IBD has been little studied. Lnc RNA is an RNA molecule that regulates gene expression and regulates a variety of molecular pathways involved in the pathbiology of IBD. Targeting IBD-associated lnc RNAs may promote personalized treatment of IBD and have therapeutic value for IBD patients. Therefore, this review summarized the effects of lnc RNA on the intestinal epithelial barrier, inflammatory response and immune homeostasis in IBD, and summarized the potential of lnc RNA as a biomarker of IBD and as a predictor of therapeutic response to IBD in the future.
Keywords: inflammatory bowel disease, long non-coding RNA, intestinal barrier, Immune homeostasis, biomarkers
Received: 25 Mar 2024; Accepted: 13 May 2024.
Copyright: © 2024 Hu, Lu, Fang, Zhang, Zheng, Zheng, Ye, Chen, Ding and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yifan Lu, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Qizhe Zhang, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Zhuoqun Zheng, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Xiaojuan Zheng, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Yanping Chen, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Jin Ding, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
Jianfeng Yang, Hangzhou First People's Hospital, Hangzhou, 310006, Zhejiang Province, China
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