@ARTICLE{10.3389/fmars.2021.816861, AUTHOR={Wen, Zheng-Yong and Qin, Chuan-Jie and Lv, Yun-Yun and Li, Yan-Ping and Zou, Yuan-Chao and Guo, Sheng-Tao and Shi, Qiong}, TITLE={Homeostasis Regulation by Potassium Channel Subfamily K Member 3 (KCNK3) in Various Fishes}, JOURNAL={Frontiers in Marine Science}, VOLUME={8}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fmars.2021.816861}, DOI={10.3389/fmars.2021.816861}, ISSN={2296-7745}, ABSTRACT={Potassium channels are important for K+ transport and cell volume regulation, which play important roles in many biological processes such as hormone secretion, ion homeostasis, excitability, and cell development. In mammals, a total of 15 potassium channels were identified and they were divided into six subfamilies, including TALK (TALK1, TALK2, TASK2), TASK (TASK1, TASK3, TASK5), TREK (TREK1, TREK2, TRAAK), TWIK (TWIK1, TWIK2, KCNK7), THIK (THIK1, THIK2) and TRESK. TASK1, also known as potassium channel subfamily k member 3 (KCNK3), is the first member identified in the TASK subfamily. This K2P channel has potential applications in fish breeding and aquaculture industry due to its important roles in various physiological processes. Despite its functional role has been well studied in mammals; however, it is less known in fishes. In this review, we systematically summarize recent research advances of this critical potassium channel in representative fishes, such as gene number variation, tissue distribution, phylogeny, and potential homeostasis regulation role. This paper provides novel insights into the functional properties of these fish kcnk3 genes (including osmoregulation, energy homeostasis maintenance and fatty acids metabolism regulation), and also expands our knowledge about their variations among diverse fishes.} }