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Front. Microbiol. | doi: 10.3389/fmicb.2018.00151

Gut microbiota: an integral moderator in health and disease

Qingqing Feng1,  Wei-Dong Chen2, 3 and  YAN-DONG WANG1*
  • 1Beijing University of Chemical Technology, China
  • 2Henan University, China
  • 3Inner Mongolia Medical University, China

The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system. Moreover, several microRNAs participate in signaling networks through the intervention of the gut microbiota. The interaction between the gut microbiota and miRNAs plays a crucial role in vascular dysfunction and hepatocellular carcinoma (HCC). In this review, we will report and discuss recent findings about the crosstalk between the gut microbiota and physical organs and how the gut microbiota and miRNAs regulate each other while influencing the host via genes, proteins or metabolites.

Keywords: Gut Microbiota, miRNA, Intestinal disease, Liver disease, Lung

Received: 19 Sep 2017; Accepted: 23 Jan 2018.

Edited by:

Miguel A. Aon, National Institute on Aging (NIH), United States

Reviewed by:

Roberto Mazzoli, Università degli Studi di Torino, Italy
Allison Clark, Open University of Catalonia, Spain  

Copyright: © 2018 Feng, Chen and WANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. YAN-DONG WANG, Beijing University of Chemical Technology, Beijing, China, ydwangbuct2009@163.com