Original Research ARTICLE
Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response
- 1Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
- 2Department of Obstetrics & Gynecology, Shanghai East Hospital, Tong ji University School of Medicine, Shanghai, China
- 3Institut Pasteur of Shanghai (CAS), China
Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1, IL-6, TNF-α, and IFN-γ showed a dramatic increase on co-infection with S. agalactiae, while the expressions of TH17 T cells and IL-17 in the cervicovaginal lavage fluid were significantly decreased. Our results indicate that S. agalactiae inhibits C. albicans hyphal development by downregulating the expression of EFG1-Hwp1. The interaction between S. agalactiae and C. albicans may attenuate host vaginal mucosal TH17 immunity and contribute to mucosal colonization by C. albicans.
Keywords: C. albicans, S. agalactiae, Hyphal development, vaginal mucosa, Th17 response
Received: 05 Sep 2017;
Accepted: 29 Jan 2018.
Edited by:Dongsheng Zhou, Beijing Institute of Microbiology and Epidemiology, China
Reviewed by:Linqi Wang, Institute of Microbiology (CAS), China
Sean Zhang, Johns Hopkins Medicine, United States
Liping Zhu, Huashan Hospital Affiliated to Fudan University, China
Copyright: © 2018 Yu, Fu, Kong, Xuan, Wen, Chen, He, He, Guo, Zhou, Xi, Ni, Yao and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Prof. Yufeng Yao, Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China, email@example.com
Prof. Wenjuan Wu, Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China, firstname.lastname@example.org