Original Research ARTICLE
Synergistic effect of Diallyl sulphide with Zinc oxide Nanorods: A novel and effective approach for treatment of acute dermatitis in model animals
- 1Aligarh Muslim University, India
Besides inciting persistent and recurrent nosocomial afflictions, Staphylococcus aureus (S. aureus), a biofilm forming pathogen, poses an increased risk of several skin as well as respiratory tract infections as well. Emerging antimicrobial resistance trend asks to search for better alternate non-antibiotic options to combat S.aureus pathogen. In the present study, we evaluated the synergistic antimicrobial potential of Zinc oxide nanorods (ZnO-NRs) and Diallyl sulphide (DAS) emulsion against methicillin-resistant Staphylococcus aureus (MRSA). The antimicrobial assessment study suggests that the ZnO-NR and DAS emulsion effectively suppressed both sensitive S. aureus as well as MRSA isolates. The combination treatment showed enhanced activity even at a lower concentration as compared to the single treatment of ZnO-NRs and DAS emulsion alone. The ZnO-NRs-DAS showed significant inhibition of MRSA biofilm as well. The combined ZnO-NRs-DAS emulsion therapy successfully treated experimental topical dermatitis infection caused by MRSA in mice model.
Keywords: Methicillin resistant Staphylococcus aureus (MRSA), Antibacterial, Antibiofilm, ZnO-NRs, Diallyl sulphide (DAS), Skin Infection
Received: 13 Dec 2017;
Accepted: 14 Mar 2018.
Edited by:Shahper N. Khan, Interdisciplinary Biotechnology Unit, AMU, India
Reviewed by:Fohad M. Husain, King Saud University, Saudi Arabia
Barira Islam, Institute of Biophysics (ASCR), Czechia
Copyright: © 2018 RAUF, Zubair, Ateeq, Dabeer, PACHAURI, Ajmal and Owais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Mr. MOHD A. RAUF, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, firstname.lastname@example.org
Dr. Swaleha Zubair, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, email@example.com
Prof. Mohammad Owais, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, firstname.lastname@example.org