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Front. Microbiol. | doi: 10.3389/fmicb.2019.01305

Role of the microbiota in the modulation of vaccine immune responses

  • 1University of Siena, Italy
  • 2Azienda Ospedaliera Universitaria Senese, Italy
  • 3Department of Medical Biotechnologies, University of Siena, Italy

The human immune system and the microbiota co-evolve and their balanced relationship is based on crosstalk between the two systems through the course of life. This tight association and the overall composition and richness of the microbiota play an important role in the modulation of host immunity and may impact on the immune response to vaccination. The availability of innovative technologies, such as next-generation sequencing and correlated bioinformatics tools, allows a deeper investigation of the crosstalk between the microbiota and human immune responses. This review discusses the current knowledge on the influence of the microbiota on the immune response to vaccination and novel tools to deeply analyze the impact of the microbiome on vaccine responses.

Keywords: Gut micobiota, Microbioma, Vaccines, Immune System, NGS - next generation sequencing

Received: 12 Feb 2019; Accepted: 27 May 2019.

Edited by:

Daniel M. Altmann, Imperial College London, United Kingdom

Reviewed by:

Cliff A. Magwira, Sefako Makgatho Health Sciences University, South Africa
Nicholas Grassly, Imperial College London, United Kingdom  

Copyright: © 2019 Ciabattini, Olivieri, Lazzeri and Medaglini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
PhD. Annalisa Ciabattini, University of Siena, Siena, 53100, Tuscany, Italy,
Prof. Donata Medaglini, University of Siena, Department of Medical Biotechnologies, Siena, 53100, Italy,