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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Microbiol. | doi: 10.3389/fmicb.2019.02627

A tug of war: DNA Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection

  • 1Fujian Medical University, China
  • 2Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, China

Cytosolic DNA sensors are the most recently described class of pattern recognition receptors (PRRs), which finally induce the transcription of type I interferons (IFN-I) and trigger the induction of a rapid and efficient innate immune response. Herpes simplex virus type I (HSV-1), a typical DNA virus, has displayed the ability to manipulate and evade host antiviral innate immune responses. Therefore, with an aim to highlight IFN-I mediated innate immune response in a battle against viral infection, here we summarize the current understanding of DNA sensing signal pathways and most recent findings on the molecular mechanisms utilized by HSV-1 to counteract antiviral immune responses. A comprehensive understanding of the interplay between HSV-1 and host early antiviral immune responses will contribute to the development of novel therapies and vaccines in the future.

Keywords: HSV-1, DNA sensor, Immune Evasion, interferon, antiviral immunity

Received: 28 Jul 2019; Accepted: 29 Oct 2019.

Copyright: © 2019 Zheng and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Chunfu Zheng, Fujian Medical University, Fuzhou, China, zheng.alan@hotmail.com