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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1385582
This article is part of the Research Topic Impact and Control of Food- and Waterborne Protozoan Parasites View all 4 articles

Identification of novel biomarkers for anti-Toxoplasma gondii IgM detection and the potential application in rapid diagnostic fluorescent tests

Provisionally accepted
Ngoc M. Nguyen Ngoc M. Nguyen 1Seon-Ju Yeo Seon-Ju Yeo 2,3Hyun Park Hyun Park 1*
  • 1 School of Medicine Wonkwang University, Iksan, Republic of Korea
  • 2 Institute of Endemic Diseases, Medical Research Center, Seoul National University, Seoul, Republic of Korea
  • 3 Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Toxoplasmosis, while often asymptomatic and prevalent as a foodborne disease, poses a considerable mortality risk for immunocompromised individuals and during pregnancy. Point-ofcare serological tests that detect specific IgG and IgM in patient sera are critical for disease management under limited resources. Despite many efforts to replace the T.gondii total lysate antigens (TLA) by recombinant antigens (rAgs) in commercial kits, while IgG detection provides significant specificity and sensitivity, IgM detection remains comparatively low in sensitivity. In this study, we attempted to identify novel antigens targeting IgM in early infection, thereby,

    Keywords: Toxoplasma gondii, diagnosis, IgM detection, Point of care test, fluorescence immunochromatographic test, 2DE immunoblotting

    Received: 13 Feb 2024; Accepted: 03 May 2024.

    Copyright: © 2024 Nguyen, Yeo and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hyun Park, School of Medicine Wonkwang University, Iksan, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.