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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1404319

Engineering principles for rationally design therapeutic strategies against hepatocellular carcinoma Provisionally Accepted

  • 1UNAM Instituto de Ecología, Mexico
  • 2Center for Research and Advanced Studies, National Polytechnic Institute of Mexico (CINVESTAV), Mexico
  • 3Department of Automatic Control, Center for Research and Advanced Studies (CINVESTAV), Mexico
  • 4Center for Complexity Sciences, National Autonomous University of Mexico, Mexico

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The search for new therapeutic strategies against cancer has favored the emergence of rationally designed treatments. These treatments have focused on attacking cell plasticity mechanisms to block the transformation of epithelial cells into cancerous cells. The aim of these approaches was to control particularly lethal cancers such as hepatocellular carcinoma. However, they have not been able to control the progression of cancer for unknown reasons. Facing this scenario, emerging areas such as systems biology propose using engineering principles to design and optimize cancer treatments.Beyond the possibilities that this approach might offer, it is necessary to know whether its implementation at a clinical level is viable or not. Therefore, in this paper, we will review the engineering principles that could be applied to rationally design strategies against hepatocellular carcinoma, and discuss whether the necessary elements exist to implement them. In particular, we will emphasize whether these engineering principles could be applied to fight hepatocellular carcinoma.

Keywords: Hepatocellular Carcinoma, Cancer, rational design, Cell plasticity, Medical systems biology

Received: 20 Mar 2024; Accepted: 23 May 2024.

Copyright: © 2024 Hernández Magaña, Bensussen, Martínez-García and Álvarez-Buylla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Juan Carlos Martínez-García, Department of Automatic Control, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico
Prof. Elena R Álvarez-Buylla, UNAM Instituto de Ecología, Mexico City, Mexico