Frontiers in Molecular Biosciences

Original Research

Accepted on 16 May 2025

Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus

in Molecular Diagnostics and Therapeutics

Guanfei Zhao
Haolong Li
Yutong Miao
Linlin Cheng
Yuying Chen
Yuan Huang
Hongyun Zhao
Yongmei Liu
Yongzhe Li
Rui Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585847

Original Research

Published on 16 May 2025

Effect of antagomir-22-3p treatment on skeletal muscle growth in intrauterine growth-restricted lambs

in RNA Networks and Biology

S. K. Duckett
M. A. Greene
A. N. S. Udoka
R. R. Powell
T. F. Bruce
J. L. Klotz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1547182

298 views

Original Research

Published on 16 May 2025

Metabolic reprogramming signature predicts prognosis and immune landscape in small cell lung cancer: MOCS2 validation and implications for personalized therapy

in Metabolomics

Junyan Wang
Panpan Sun
Fan Zhang
Yu Xu
Shenghu Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1592888

374 views

Original Research

Published on 16 May 2025

Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling

in Molecular Diagnostics and Therapeutics

Guobin Qiu
Zhiyong Wu
Dunhui Yang
Luqiu Zhou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1598413

176 views

Brief Research Report

Published on 16 May 2025

Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

in Molecular Diagnostics and Therapeutics

Hao Chen
Yang Zhong
Rongjie Feng
Xingyu Zhu
Kang Xu
Mingjie Kuang
Wei Chong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556736

273 views

Original Research

Published on 16 May 2025

Serotoninergic modulation in the brainstem and hypothalamus of female overnourished rats: impact on mitochondrial markers, oxidative stress and BDNF mRNA levels

in Cellular Biochemistry

Thyago de Oliveira Rodrigues
Osmar Henrique dos Santos Júnior
Maria Daniele Teixeira Beltrão de Lemos
Matheus Santos de Sousa Fernandes
Fatma Hilal Yagin
Burak Yagin
Samarjit Das
Abdullah F. Alghannam
Pablo Prieto-González
Claudia J. Lagranha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1564061

166 views

Review

Accepted on 15 May 2025

Insights from Veterinary Models for Advancing Oncolytic Virotherapy Through Comparative Oncology

in Molecular Diagnostics and Therapeutics

Almohanad A Alkayyal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1615393

Original Research

Published on 15 May 2025

Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics

in Molecular Biophysics

Charles B. Reilly
Joel Moore
Shanda Lightbown
Austin Paul
Sylvie G. Bernier
Kenneth E. Carlson
Donald E. Ingber

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1575747

668 views

Original Research

Published on 15 May 2025

Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Chenxuyu Zhang
Zheng Luo
Liang Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1554304

419 views

Original Research

Published on 15 May 2025

A glutamine metabolism gene signature with prognostic and predictive value for colorectal cancer survival and immunotherapy response

in Molecular Diagnostics and Therapeutics

Yinmeng Zhang
He Zhu
Jiawei Fan
Jiahui Zhao
Yan Xia
Nan Zhang
Hong Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599141

227 views

Editorial

Published on 15 May 2025

Editorial: Advancements and future challenges in molecular diagnostics and therapeutics

in Molecular Diagnostics and Therapeutics

Matteo Becatti
Masoud Mozafari
Roberta Risoluti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1620909

153 views

Original Research

Published on 14 May 2025

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Cenzhu Wang
Ying Fang
Yuhan Zhang
Shuhan Feng
Rui Hou
Hanfang Fan
Zeyu Wang
Lei Liu
Junli Ding
Junying Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1600626

285 views

Original Research

Published on 14 May 2025

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibak Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597130

397 views

Methods

Published on 13 May 2025

Thioflavin T in-gel staining for ex vivo analysis of cardiac amyloid

in Protein Biochemistry for Basic and Applied Sciences

Joseph Oldam
Irina Tchernyshyov
Jennifer Van Eyk
Juan Troncoso
Charles G. Glabe
Giulio Agnetti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1505250

359 views

Review

Published on 13 May 2025

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

in Molecular Diagnostics and Therapeutics

Ziling Pang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578693

291 views

Review

Accepted on 12 May 2025

Unravelling Drug Resistance in Leishmaniasis: Genomic Adaptations and Emerging Therapies

in Molecular Diagnostics and Therapeutics

Chandra Kanta Bhusal
Shweta Sinha
Davinder Kaur Chechi
Rakesh Sehgal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1573618

193 views