EDITORIAL article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
This article is part of the Research TopicThe Role of Calcium Channels in Human Health and Disease Volume IIIView all 15 articles
Editorial: The role of calcium channels in human health and disease - Volume III
Provisionally accepted
- 1Longgang ENT Hospital, Institute of ENT and Shenzhen Key Laboratory of ENT, Shenzhen, China
- 2Kunming Medical University, Kunming, China
- 3Emory University, Atlanta, United States
- 4Southern University of Science and Technology, Shenzhen, China
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Calcium channels, situated on the cell membrane or organelle membranes, play a pivotal role in regulating the transmembrane flux of calcium ions. These channels are integral to cellular signal transduction, facilitating action potentials and neurotransmitter release in cells (Berridge, 2012). The precise regulation of calcium channels is crucial for maintaining cardiac rhythm, vascular tone, and cognitive functions such as learning and memory. Pathological conditions often involve calcium channel dysfunction, which is closely associated with arrhythmias, hypertension, epilepsy, neurodegenerative diseases, tumors, and pain (Liu et al., 2019). Consequently, understanding the regulation of calcium channels is vital for elucidating the mechanisms governing calcium homeostasis and various physiological processes. This special Research Topic presents fourteen studies exploring novel roles of calcium channels in pathophysiological contexts. In summary, this Research Topic underscored the essential roles of calcium channels in human health and disease. Despite significant advancements in elucidating the structure and function of calcium channels, a comprehensive and systematic characterization of their roles in calcium homeostasis remains a long-term objective.
Keywords: Calcium Channels, Calcium signal, Human Disease, Human health, Therapeutic target
Received: 04 Feb 2026; Accepted: 11 Feb 2026.
Copyright: © 2026 Zhang, Zheng, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peng Zhang
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