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Correction ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00275

Corrigendum: Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD

 Jian Bao1,  Yacoubou A. Mahaman1,  Rong Liu1,  Jian-Zhi Wang1, 2, Zhiguo Zhang3, Bin Zhang4 and  Xiaochuan Wang1, 2*
  • 1Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, China
  • 2Co-innovation Center of Neuroregeneration, Nantong University, China
  • 3School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, China
  • 4Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, United States

In the original article, due to the author's oversight, there was several mistakes in Figure 3C and Figure 4C as published. The image "PSD95 of Female" in Figure 3C were inadvertently replaced with image from "GSK3β" in Figure 5C. The images "AT8 of Female" and "PS262 of Female" in Figure 4C were inadvertently replaced with image from "PS404 of Female" in Figure 4C. The images "Tau5 of Female" in Figure 4C were inadvertently replaced with image from "Tau5 of Male" in Figure 4A. The corrected Figure 3C and Figure 4C appear below. The quantification for the above-mentioned blots have been done in corrected Figure 3D and Figure 4D, which all have no significant difference between control and STZ groups like the published original version of the article. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. FIGURE 3 | Sex influences synaptic plasticity in the sporadic AD animal model. (A,C) Western blot analysis of the protein levels of synapsin-1, synaptagmin, psd95, psd93, NR2A, and NR2B and (B,D) their quantitative analysis for male or female rats. DM1A was used as a loading control. The data were expressed as mean ± SD (n = 4). ***P <0.001 vs. the vehicle control. Data were analyzed using t-test. their quantitative analysis for male or female rats. The data were expressed as mean ± SD (n = 4). The phosphorylation level of tau was normalized to total tau level probed by Tau5. The total level of tau was normalized DM1A. ***P <0.001 vs. the vehicle control. Data were analyzed using t-test. **P <0.01 vs. the vehicle control.The original article has been updated.

Keywords: Alzhcimer's disease, animal model, Streptozotocin, Sex diff erences, Learning and memeory

Received: 24 Aug 2019; Accepted: 25 Sep 2019.

Copyright: © 2019 Bao, Mahaman, Liu, Wang, Zhang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xiaochuan Wang, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China, wxch@mails.tjmu.edu.cn