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Correction ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00292

Corrigendum: Age-Dependent Relationship Between Plasma Aβ40 and Aβ42 and Total Tau Levels in Cognitively Normal Subjects

 Ming-Jang Chiu1*,  Lih-Fen Lue2, Ming-Chyi Pai2, 3,  Ta-Fu Chen4,  Chaur-Jong Hu5, 6,  Likai Huang5, 6,  Wei-Che Lin7,  Chau-Chung Wu8,  Jiann-Shing Jeng4,  Kaj Blennow9, 10,  Marwan N. Sabbagh11, Sui-Hing Yan12,  Pei-Ning Wang13, 14,  Shieh-Yueh Yang15, 16, Hiroyuki Hatsuta17, 18,  Satoru Morimoto17, 19,  Akitoshi Takeda18, Yoshiaki Itoh18, Jun Liu20 and  Haiqun Xie21
  • 1National Taiwan University, Taiwan
  • 2Banner Sun Health Research Institute, United States
  • 3National Cheng Kung University, Taiwan
  • 4Department of Neurology, National Taiwan University Hospital, Taiwan
  • 5Taipei Medical University, Taiwan
  • 6Shuang Ho Hospital, Taipei Medical University, Taiwan
  • 7Kaohsiung Chang Gung Memorial Hospital, Taiwan
  • 8Department of Internal Medicine, National Taiwan University Hospital, Taiwan
  • 9Sahlgrenska University Hospital, Sweden
  • 10University of Gothenburg, Sweden
  • 11Lou Ruvo Center for Brain Health, Cleveland Clinic, United States
  • 12Taipei City Hospital, Taiwan
  • 13National Yang-Ming University, Taiwan
  • 14Taipei Veterans General Hospital, Taiwan
  • 15MagQu, Taiwan
  • 16MagQu LLC, United States
  • 17Hatsuta Neurology Clinic, Japan
  • 18Department of Neurology, Osaka City University, Japan
  • 19Department of Physiology, School of Medicine, Keio University, Japan
  • 20Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China
  • 21Department of Neurology, First People's Hospital of Foshan, China

In the original article, there were errors in the name of participating site. One of the participating site is written as Keio University Hospital. The correct site is Hatsuta Neurology Clinic, not Keio University Hospital.

A correction has been made to the Table 1 Legend,
NTUH, National Taiwan University Hospital; NCKUH, National Cheng Kung University Hospital; SHH, Shuang Ho Hospital; KCGMH, Kaohsiung Chang Gung Memorial Hospital; SUH, Sahlgrenska University Hospital; BSHRI, Banner Sun Health Research Institute; RAH, Renai Branch Taipei City Hospital; TVGHL, Taipei Veterans General Hospital; SYSMH, Sun Yet-Sen Memory Hospital; FH, Foshan Hospital; HNC, Hatsuta Neurology Clinic; OCUH, Osaka City University; SD, standard deviation.

A correction has been made to the Table 1,
Table 1. The means and standard deviations (SD) of age (years) of the normal-cognition subjects in each participating site*

A correction has been made to the Materials and Methods section.
Participating Sites
A total of 391 cognitively normal subjects aged 23–91 were enrolled from 2010 to 2018 from the following six hospitals in Taiwan: National Taiwan University Hospital (NTUH), Taipei Medical University Shuang-Ho Hospital (SHH), Renai Branch of Taipei City Hospital (RAH), Taipei Veterans General Hospital (TVGH), National Cheng Kung University Hospital (NCKUH), and Kaohsiung Chang Gung Memorial Hospital (KCGMH); Sahlgrenska University Hospital (SUH) in Guttenberg, Sweden; Banner Sun Health Research Institute (BSHRI) in Sun City, AZ, USA; two hospitals in the cities of Foshan, Foshan Hospital (FH) and Guangzhou, Sun Yat-Sen Memorial Hospital (SYSMH), Guangdong, China; and finally two hospitals in Japan: Hatsuta Neurology Clinic (HNC) in Osaka, and Osaka City University Hospital (OCUH) in Osaka. All participants were older than 21 years of age and gave their own written informed consent. The study was approved by the Institutional Review Board (IRB) or Research Ethics Committee (REC) of each participating hospital in the respective countries, namely, NTUH REC, Taipei Medical University-Joint IRB for SHH, Taipei City Hospital REC for RAH, TVGH IRB, NCKUH IRB, KCGMH IRB, Central Ethical Review Board-University of Gothenburg for SUH, Banner Health IRB for BSHRI, Sun Yat-Sen University Hospital (SYSUH) Cancer Center IRB, Asai Dermatology Clinic IRB and Osaka City University IRB.

Cognition Assessment and Criteria for Recruitment
The purpose of the recruitment criteria was to exclude subjects with diagnoses of MCI and dementia. All study sites followed the NIA-AA criteria for the diagnosis of dementia and MCI due to AD (Albert et al., 2011; McKhann et al., 2011). In addition to clinical criteria, basic cognitive assessment tools [Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR)] were also used. The criteria for normal cognition were MMSE _ 28 and CDR = 0. Brain imaging and CSF biomarkers were used as supplementary tools. Brain (FDG)-PET were used by HNC/OCUH, Japan, and Subjects from SUH, Sweden had CSF Ab > 530 pg/ml and t-Tau < 350 pg/ml (Sutphen et al., 2015; Teunissen et al., 2018). Subjects who had acute or chronic systemic diseases or neuropsychiatric disorders, visual or auditory dysfunction severe enough to interfere with cognitive assessments were all excluded


The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: Alzheimer, Plasma, Amyloid, tau, Immunomagnetic reduction

Received: 01 Oct 2019; Accepted: 09 Oct 2019.

Copyright: © 2019 Chiu, Lue, Pai, Chen, Hu, Huang, Lin, Wu, Jeng, Blennow, Sabbagh, Yan, Wang, Yang, Hatsuta, Morimoto, Takeda, Itoh, Liu and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Ming-Jang Chiu, National Taiwan University, Taipei, Taiwan, mjchiu@ntu.edu.tw