@ARTICLE{10.3389/fnagi.2021.626974, AUTHOR={Hansen, Niels and Singh, Aditya and Bartels, Claudia and Brosseron, Frederic and Buerger, Katharina and Cetindag, Arda C. and Dobisch, Laura and Dechent, Peter and Ertl-Wagner, Birgit B. and Fliessbach, Klaus and Haynes, John D. and Heneka, Michael T. and Janowitz, Daniel and Kilimann, Ingo and Laske, Christoph and Metzger, Coraline D. and Munk, Matthias H. and Peters, Oliver and Priller, Josef and Roy, Nina and Scheffler, Klaus and Schneider, Anja and Spottke, Annika and Spruth, Eike J. and Teipel, Stefan and Tscheuschler, Maike and Vukovich, Ruth and Wiltfang, Jens and Duezel, Emrah and Jessen, Frank and Goya-Maldonado, Roberto}, TITLE={Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline}, JOURNAL={Frontiers in Aging Neuroscience}, VOLUME={13}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fnagi.2021.626974}, DOI={10.3389/fnagi.2021.626974}, ISSN={1663-4365}, ABSTRACT={Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.} }