Corrigendum: PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease
Federico Angelo Cazzaniga1 
Edoardo Bistaffa1 Chiara Maria Giulia De Luca1,2 Sara Maria Portaleone3 
Marcella Catania1 Veronica Redaelli1 
Irene Tramacere4 Giuseppe Bufano1 Martina Rossi2† 
Paola Caroppo1 
Anna Rita Giovagnoli1 Pietro Tiraboschi1 
Giuseppe Di Fede1 
Roberto Eleopra5 
Grazia Devigili5 
Antonio Emanuele Elia5 
Roberto Cilia5 
Michele Fiorini6 
Matilde Bongianni6 
Giulia Salzano2† 
Luigi Celauro2 
Federico Giuseppe Quarta3 Angela Mammana7 
Giuseppe Legname2 
Fabrizio Tagliavini8 
Piero Parchi7,9 
Gianluigi Zanusso6 
Giorgio Giaccone1 
Fabio Moda1*- 1Unit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- 2Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
- 3Department of Health Sciences, Otolaryngology Unit, ASST Santi Paolo e Carlo Hospital, Università degli Studi di Milano, Milan, Italy
- 4Department of Research and Clinical Development, Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- 5Unit of Neurology 1 – Parkinson's and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- 6Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
- 7IRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy
- 8Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- 9Department of Diagnostic Experimental and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy
A corrigendum on
PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease
by Cazzaniga, F. A., Bistaffa, E., De Luca, C. M. G., Portaleone, S. M., Catania, M., Redaelli, V., Tramacere, I., Bufano, G., Rossi, M., Caroppo, P., Giovagnoli, A. R., Tiraboschi, P., Di Fede, G., Eleopra, R., Devigili, G., Elia, A. E., Cilia, R., Fiorini, M., Bongianni, M., Salzano, G., Celauro, L., Quarta, F. G., Mammana, A., Legname, G., Tagliavini, F., Parchi, P., Zanusso, G., Giaccone, G., and Moda, F. (2022). Front. Aging Neurosci. 14:848991. doi: 10.3389/fnagi.2022.848991
In the published article, there was an error in Figure 5 as published. In particular, the Western blot showed in the original Figure 5D related to the 1st round of PMCA of patient 19 (19_BH) was mistakenly selected and has now been replaced with the correct one. The corrected Figure 5D and its caption appear below.
Figure 5. Quantitative PMCA (qPMCA) for estimating PrPres concentration in OM samples of sCJD patients. (A) Serial dilutions of recombinant full-length human PrP (recHuPrP23−231) were used to estimate prion concentration in the brain of sCJD patients. (B) Serial dilutions of sCJD brain homogenates subjected to PK and PNGase treatments before Wb analysis. Quantitative PMCA to estimate PrPres concentration in OM of (C) MM1, (D) MV2, and (E) VV2 patients. Specific rounds at which every OM PrPres was detected (3rd for the MM1 and one VV2, 5th for one MV2 and one VV2, and 6th for one MV2) are shown.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: Creutzfeldt–Jakob disease, olfactory mucosa, protein misfolding cyclic amplification, neurodegeneration, prion, peripheral biomarker
Citation: Cazzaniga FA, Bistaffa E, De Luca CMG, Portaleone SM, Catania M, Redaelli V, Tramacere I, Bufano G, Rossi M, Caroppo P, Giovagnoli AR, Tiraboschi P, Di Fede G, Eleopra R, Devigili G, Elia AE, Cilia R, Fiorini M, Bongianni M, Salzano G, Celauro L, Quarta FG, Mammana A, Legname G, Tagliavini F, Parchi P, Zanusso G, Giaccone G and Moda F (2023) Corrigendum: PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease. Front. Aging Neurosci. 15:1073356. doi: 10.3389/fnagi.2023.1073356
Received: 18 October 2022; Accepted: 13 February 2023;
Published: 27 February 2023.
Edited and reviewed by: Rodrigo Morales, University of Texas Health Science Center at Houston, United States
Copyright © 2023 Cazzaniga, Bistaffa, De Luca, Portaleone, Catania, Redaelli, Tramacere, Bufano, Rossi, Caroppo, Giovagnoli, Tiraboschi, Di Fede, Eleopra, Devigili, Elia, Cilia, Fiorini, Bongianni, Salzano, Celauro, Quarta, Mammana, Legname, Tagliavini, Parchi, Zanusso, Giaccone and Moda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fabio Moda, fabio.moda@istituto-besta.it
†Present addresses: Martina Rossi, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
Giulia Salzano, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom