CORRECTION article

Front. Neural Circuits, 06 September 2021

Volume 15 - 2021 | https://doi.org/10.3389/fncir.2021.727442

Corrigendum: Inhibitory Network Bistability Explains Increased Interneuronal Activity Prior to Seizure Onset

  • 1. Division of Clinical and Computational Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON, Canada

  • 2. Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, ON, Canada

  • 3. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada

  • 4. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

  • 5. Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada

  • 6. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada

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In the original article, there was a mistake in Table 1 as published. The values of d and klow were swapped between the Control and 4-AP settings in this table, but correct in the associated code. The corrected Table 1 appears below.

Table 1

ParameterValue (Control)Value (4-AP)Rationale
Cm73 pF49 pFUnpublished in-house experiment
vr−60.6 mV−60.6 mVFerguson et al. (2013)
vt−43.1 mV−43.1 mVFerguson et al. (2013)
vpeak2.5 mV2.5 mVFerguson et al. (2013)
a0.01 ms−10.01 ms−1Parameter influences rheobase and adaptation exhibited by model*
b−0.2 nS−0.4 nSParameter influences rheobase and adaptation exhibited by model*
c−67 mV−67 mVFerguson et al. (2013)
d0.75 pA1.25 pAParameter influences rheobase and adaptation exhibited by model*
klow0.6 nS/mV0.4 nS/mVParameter influences rheobase and adaptation exhibited by model*
khigh2 nS/mV2 nS/mVParameter influences rheobase and adaptation exhibited by model*

Parameters used in neuron models.

*

Differences in rheobase and adaptation in control and 4-AP neurons are features shown by Williams and Hablitz (2015) as well as observed in our un-published in-house experiment.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

  • 1

    FergusonK. A.HuhC. Y.AmilhonB.WilliamsS.SkinnerF. K. (2013). Experimentally constrained ca1 fast-firing parvalbumin-positive interneuron network models exhibit sharp transitions into coherent high frequency rhythms. Front. Comput. Neurosci.7:144. 10.3389/fncom.2013.00144

  • 2

    WilliamsS. B.HablitzJ. J. (2015). Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K+ channels and Ih. Front. Cell. Neurosci.9:89. 10.3389/fncel.2015.00089

Summary

Keywords

epilepsy, seizure, bistability, computational neuroscience, synchrony, inhibitory network, interneurons

Citation

Rich S, Moradi Chameh H, Rafiee M, Ferguson K, Skinner FK and Valiante TA (2021) Corrigendum: Inhibitory Network Bistability Explains Increased Interneuronal Activity Prior to Seizure Onset. Front. Neural Circuits 15:727442. doi: 10.3389/fncir.2021.727442

Received

18 June 2021

Accepted

12 August 2021

Published

06 September 2021

Volume

15 - 2021

Edited by

Qian-Quan Sun, University of Wyoming, United States

Reviewed by

Qing Yun Wang, Beihang University, China

Updates

Copyright

*Correspondence: Scott Rich

†These authors share senior authorship

‡Present address: Katie Ferguson, Department of Neuroscience, Yale University School of Medicine, New Haven, CT, United States

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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