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Neuroendocrine Research in Health and Disease

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Front. Neurosci. | doi: 10.3389/fnins.2019.00021

Intrapancreatic ganglia and neural regulation of pancreatic endocrine secretion

  • 1China Medical University, China

Extrapancreatic nerves project to islet directly or converage on intrapancreatic ganglia. Intrapancreatic ganglia are innervated by sympathetic, parasympathetic, enteric, sensory nerve fibers and other intrapancreatic ganglia. Neurotransmitters of intrapancreatic ganglia and external nerves modulate the islet secretion altogether. Electrical properties of pancreatic neurons and pancreatic ganglionic transmission can affect the pancreatic endocrinal secretion. Both intrapancreatic ganglia and extrapancreatic nerves have an important influence on pancreatic endocrinal functions. This review summarize the effects of intrapancreatic ganglia and extrapancreatic nerves on endocrinal functions, but further researches are needed to clarify the roles and the mechanisms of intrapancreatic ganglia in physiological and disease states of pancreas, which may provide new approaches to treat pancreas diseases.

Keywords: Intrapancreatic ganglia, extrapancreatic nerves, Pancreas, islet, Insulin

Received: 12 Jul 2018; Accepted: 10 Jan 2019.

Edited by:

Lee E. Eiden, National Institutes of Health (NIH), United States

Reviewed by:

Qingchun Tong, University of Texas Health Science Center at Houston, United States
Youssef Anouar, Institut National de la Santé et de la Recherche Médicale (INSERM), France  

Copyright: © 2019 Li, Yu, Liu and Sha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Lei Sha, China Medical University, Shenyang, 110001, Liaoning Province, China, lsha@cmu.edu.cn