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Methods ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.00784

A 3D-Printed Device for Low Cost Neural Stimulation in Mice

  • 1Department of Mechanical and Industrial Engineering, University of Toronto, Canada
  • 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada
  • 3Ibero American University, Mexico
  • 4KITE, Toronto Rehabilitation Institute, University Health Network, Canada
  • 5Department of Surgery, University of Toronto, Canada
  • 6Department of Materials Science and Engineering, University of Toronto, Canada

Electrical stimulation of the brain through the implantation of electrodes is an effective treatment for certain diseases and the focus of a large body of research investigating new cell mechanisms, neurological phenomena, and treatments. Electrode devices developed for stimulation in rodents vary widely in size, cost, and functionality, with the majority of recent studies presenting complex, multi-functional designs. While some experiments require these added features, others are in greater need of reliable, low cost, and readily available devices that will allow surgeries to be scheduled and completed without delay. In this work, we utilize 3D printing and common electrical hardware to produce an effective 2-channel stimulation device that meets these requirements. Our stimulation electrode has not failed in over 60 consecutive surgeries, costs less than $1 USD, and can be assembled in less than 20 minutes. 3D printing minimizes the amount of material used in manufacturing the device and enables one to match the curvature of the connector’s base with the curvature of the mouse skull, producing an ultra-lightweight, low size device with improved adhesion to the mouse skull. The range of the stimulation parameters used with the proposed device was: pulse amplitude 1-200 μA, pulse duration 50-500 μs and pulse frequency 1-285Hz.

Keywords: 3D printing, Brain Stimulation, neural implant, manufacturing, platinum wire electrode

Received: 16 Apr 2019; Accepted: 12 Jul 2019.

Edited by:

Yen-Chung Chang, National Tsing Hua University, Taiwan

Reviewed by:

Xavier Navarro, Autonomous University of Barcelona, Spain
Michael T. Lippert, Leibniz Institute for Neurobiology (LG), Germany  

Copyright: © 2019 Morrison, Sefton, Marquez-Chin, Popovic, Morshead and Naguib. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Milos R. Popovic, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, Ontario, Canada, milos.popovic@utoronto.ca
Prof. Cindi M. Morshead, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, Ontario, Canada, cindi.morshead@utoronto.ca
Prof. Hani E. Naguib, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Ontario, Canada, naguib@mie.utoronto.ca