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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01184

Analysis of gut microflora in patients with Parkinson’s disease

  • 1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, China
  • 2Institute of Microbiology, Chinese Academy of Sciences, China
  • 3Neurology Department of China-Japan Friendship Hospital, China
  • 4Chinese Academy of Sciences, China

This study was conducted to explore the composition of the fecal microflora of Chinese Parkinson’s disease (PD) patients, as well as to explore links between PD clinical features and antiparkinsonian medications on gut microflora. 72 PD cases [59 patients suffering from PD for > 1 year (OPD) and 13 new PD (NPD) patients] were studied. Microflora communities in the feces of the patients and corresponding healthy controls were examined using high-throughput Illumina MiSeq sequencing targeting the 16S rRNA gene. The gut microflora of OPD patients contained high level of Rikenellaceae compared to corresponding HCs. In addition, significantly higher levels of Turicibacteraceae, was found in the NPD group compared to the corresponding HCs. The genera Turicibacter and Prevotella were significantly correlated with the PD severity scores. Our findings that some fecal microflora were closely related to PD clinical characteristics may enhance our understanding of the pathogenesis and treatment of PD.

Keywords: Turicibacter, Prevotella, 16S rRNA gene, Gut microflora, Parkinson’s disease

Received: 15 Mar 2019; Accepted: 18 Oct 2019.

Copyright: © 2019 JIN, Li, LIU, Lyu, Wang, Wang, LIANG, TAO, Zhu and ALKASIR. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. RASHAD ALKASIR, Chinese Academy of Sciences, Beijing, China, rashad.84@hotmail.com