%A Hawkes,Richard %D 2014 %J Frontiers in Systems Neuroscience %C %F %G English %K zebrin II,phospholipase Cß4,Purkinje cell,stripes,Long-term depression %Q %R 10.3389/fnsys.2014.00041 %W %L %M %P %7 %8 2014-March-28 %9 Review %+ Dr Richard Hawkes,University of Calgary,Cell Biology & Anatomy,Calgary,T2N4N1,Alberta,Canada,rhawkes@ucalgary.ca %# %! cerebellar functional architecture %* %< %T Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse %U https://www.frontiersin.org/articles/10.3389/fnsys.2014.00041 %V 8 %0 JOURNAL ARTICLE %@ 1662-5137 %X The cerebellar cortex comprises a stereotyped array of transverse zones and parasagittal stripes, built around multiple Purkinje cell subtypes, which is highly conserved across birds and mammals. This architecture is revealed in the restricted expression patterns of numerous molecules, in the terminal fields of the afferent projections, in the distribution of interneurons, and in the functional organization. This review provides an overview of cerebellar architecture with an emphasis on attempts to relate molecular architecture to the expression of long-term depression (LTD) at the parallel fiber-Purkinje cell (pf-PC) synapse.