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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00552

Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives

Eonju Oh1,  Sukant Garg2, Ye Liu2,  Ran Gao2,  Chae-Ok Yun1,  Sunil C. Kaul2* and Renu Wadhwa2
  • 1Hanyang University, South Korea
  • 2National Institute of Advanced Industrial Science and Technology (AIST), Japan

We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10) and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells, therefore represent promising candidates for the treatment of metastatic cancers.

Keywords: Ashwagandha, TEG, Derivative, Inhibit, invasion, metastasis, therapy

Received: 21 Jul 2018; Accepted: 07 Nov 2018.

Edited by:

Giorgio Seano, Institut Curie, France

Reviewed by:

Thomas DAUBON, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Anna V. Samarelli, Università degli Studi di Modena e Reggio Emilia, Italy  

Copyright: © 2018 Oh, Garg, Liu, Gao, Yun, Kaul and Wadhwa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Sunil C. Kaul, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, 305-8560, Ibaraki, Japan, s-kaul@aist.go.jp