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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00637

Characteristics of Familial Lung Cancer in Yunnan-Guizhou Plateau of China

Xiaojie Ding1, 2,  Ying Chen1, 2*, Jiapeng Yang2, Guangjian Li2, Huatao Niu2, Rui he2, Jie Zhao2 and Huanqi Ning2
  • 1Kunming Medical University, China
  • 2Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center, China

Background:
Lung cancer has inherited susceptibility and show familial aggregation, the characteristics of familial lung cancer exhibit population heterogeneity. Despite previous studies, familial lung cancer in China’s Yunnan-Guizhou plateau remains understudied.
Methods:
Between 2015 and 2017, 1023 lung cancer patients (residents of Yunnan-Guizhou plateau) were enrolled with no limitation on other parameters, 152 subjects had familial lung cancer. Clinicopathologic parameters were analyzed and compared, 4754 lung cancer patients from NCI-GDC were used to represent a general population.
Results:
Familial lung cancer (FLC) subjects showed unique characters: early-onset; increased rate of female, adenocarcinoma, stage IV and other cancer history; unbalance in anatomic sites; all ruling out significant difference in smoking status. Unbalanced distribution of co-existing diseases or symptoms was also discovered. FLC patients were more likely to develop benign lesions (polyps, nodules, cysts) early in life, especially early-growth of multiple pulmonary nodules at higher frequency. Typical diseases with family history like diabetes and hypertension were also increased in FLC population. Compared to GDC data, our subject population was younger: the age peak of our FLC group was in 50-59; our sporadic group had an age peak around 60; while GDC patients’ age peak was in 60-69. Importantly, the biggest difference happened in age 40-49: our FLC group and sporadic group had 3 times and 2 times higher ratio than GDC population, respectively. Moreover, the age peaks of our FLC males and FLC females were both in 50-59; while our sporadic females had the age peak in 50-59, much earlier than sporadic males (around 60-69); reflecting gender-specific or age-specific characters in our subject population.
Conclusions:
Familial lung cancer in China’s Yunnan-Guizhou plateau showed unique clinicopathologic characters, differences were found in gender, age, histologic type, TNM stage and co-existing diseases or symptoms. Identification of hereditary factors which lead to increased lung cancer risk will be a challenge of both scientific and clinical significance.

Keywords: familial lung cancer, cancer susceptibility, Yunnan-Guizhou Plateau of China, Clinicopathologic characteristics, family history

Received: 09 Sep 2018; Accepted: 05 Dec 2018.

Edited by:

Yanis Boumber, Fox Chase Cancer Center, United States

Reviewed by:

Rabab M. Gaafar, Cairo University, Egypt
Janaki Deepak, University of Maryland, Baltimore, United States  

Copyright: © 2018 Ding, Chen, Yang, Li, Niu, he, Zhao and Ning. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Ying Chen, Kunming Medical University, Kunming, 650500, Yunnan Province, China, 36410008@qq.com