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Front. Oncol. | doi: 10.3389/fonc.2019.01252

High-grade serous carcinoma arising from endometriosis of the rectum complicated with ovarian cancer: a case report

Song Li1,  Aiyan Xing2, Qiuju Li1 and  Guoyun Wang1*
  • 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, China
  • 2Pathology Department, Qilu Hospital, Shandong University, China

Endometriosis is one of the most common benign gynecological diseases. it has malignant behaviors such as invasion, implantation and recurrence, and has the characteristics similar to malignant tumors. Epidemiological, clinicopathological, molecular biological and genetic evidence suggests that endometriosis can be malignant. Endometriosis-associated malignancy (EAM) was closely correlated with endometriosis in histology. EAM arise from atypical endometriosis as an intermediate lesion between endometriosis and cancer. About 80 per cent of EAM is located in the ovary, also known as endometriosis-associated ovarian cancer (EAOC). EAOC with clear cell adenocarcinoma and endometrioid carcinoma as the main pathological types of a special group of ovarian epithelial carcinoma. Extragonadal endometriosis is rare. No association between endometriosis and high-grade serous ovarian cancer or mucinous ovarian cancer has been reported to date. We first report a very rare case of high-grade serous carcinoma arising from endometriosis of the rectum complicated with ovarian cancer. A 63-year-old Chinese woman was admitted with the complaint of abdominal distention. We diagnosed the patient as having ovary carcinoma, and planned to perform cytoreductive surgery. During the operation, we found a solid mass of 12cm in the anterior wall of the rectum containing chocolate-like fluid. Histopathological examination after surgery revealed high-grade serous carcinoma arising from endometriosis of the rectum complicated with ovarian cancer. The patient received 6 cycles of chemotherapy postoperatively, consisting of carboplatin and paclitaxel, and showed no recurrence.

Keywords: endometriosis-associated malignancy, Extragonadal Endometriosis, high-grade serous carcinoma, Rectum, ovarian cancer

Received: 13 Mar 2019; Accepted: 30 Oct 2019.

Copyright: © 2019 Li, Xing, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Guoyun Wang, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong Province, China, wangguoy@sdu.edu.cn