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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01291

Title: Emerging Translational Opportunities in Comparative Oncology with Companion Canine Cancers: Radiation Oncology

  • 1Comparative Medicine Institute, North Carolina State University, United States
  • 2College of Veterinary Medicine, North Carolina State University, United States
  • 3Duke Cancer Institute, United States
  • 4School of Veterinary Medicine, University of California, Davis, United States
  • 5Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, United States

It is estimated that more than 6 million pet dogs are diagnosed with cancer annually in the USA. Both primary care and specialist veterinarians are frequently called upon to provide clinical care that improves the quality and/or quantity of life for affected animals. Because these cancers develop spontaneously in animals that often share the same environment as their owners, have intact immune systems and are of similar size to humans, and because the diagnostic tests and treatments for these cancers are similar to those used for management of human cancers, canine cancer provides an opportunity for research that simultaneously helps improve both canine and human health care. This is especially true in the field of radiation oncology, for which there is a rich and continually evolving history of learning from the careful study of pet dogs undergoing various forms of radiotherapy. The purpose of this review article is to inform readers of the potential utility and limitations of using dogs in that manner; the peer-reviewed literature will be critically reviewed, and current research efforts will be discussed. The article concludes with a look towards promising future directions and applications of this pet dog “model”.

Keywords: Radiation Oncology, Radiobiology, Canine comparative oncology, medical physics, Animal Models, Cancer models, imaging, normal tissue radiotolerance

Received: 27 Aug 2019; Accepted: 07 Nov 2019.

Copyright: © 2019 Nolan, Kent and Keara Boss. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Michael W. Nolan, Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States, mwnolan@ncsu.edu